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Ppp2r2c Gene Detail
Summary
  • Symbol
    Ppp2r2c
  • Name
    protein phosphatase 2, regulatory subunit B, gamma
  • Synonyms
    6330548O06Rik, IMYPNO1, PR52
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442660
    NCBI Gene: 269643
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:37025857-37112422 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 19.28 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2611 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442660
 protein coding gene Chr5:37024187-37112422 (+)
129S1/SvImJ ENSMUSG00200030740
 protein coding gene Chr5:32475056-32561634 (+)
A/J ENSMUSG00195027952
 protein coding gene Chr5:31940328-32025370 (+)
AKR/J ENSMUSG00220002017
 protein coding gene Chr5:31966907-32051950 (+)
BALB/cJ ENSMUSG00180023167
 protein coding gene Chr5:31743165-31828206 (+)
C3H/HeJ ENSMUSG00175018686
 protein coding gene Chr5:33727388-33812431 (+)
C57BL/6NJ ENSMUSG00215004642
 protein coding gene Chr5:32474697-32561281 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027165
 protein coding gene Chr5:31772056-31861288 (+)
CAST/EiJ ENSTCUG00005024262
 protein coding gene Chr5:31955026-32040973 (+)
CBA/J ENSMUSG00210004202
 protein coding gene Chr5:32691433-32776470 (+)
DBA/2J ENSMUSG00185016241
 protein coding gene Chr5:34558771-34645344 (+)
FVB/NJ ENSMUSG00205013881
 protein coding gene Chr5:31442846-31529426 (+)
JF1/MsJ ENSUMUG00000050097
 protein coding gene Chr5:39163337-39249113 (+)
LP/J ENSMUSG00230043777
 protein coding gene Chr5:39202220-39288790 (+)
NOD/ShiLtJ ENSMUSG00190002669
 protein coding gene Chr5:31738958-31825631 (+)
NZO/HlLtJ ENSMUSG00225015235
 protein coding gene Chr5:44373677-44460249 (+)
PWK/PhJ ENSLUMG00010022053
 protein coding gene Chr5:31846109-31933976 (+)
SPRET/EiJ ENSMSPG00010030179
 protein coding gene Chr5:33069293-33155060 (+)
WSB/EiJ ENSIUOG00005017159
 protein coding gene Chr5:34662588-34749186 (+)



Homology
more
  • Human Ortholog
    PPP2R2C, protein phosphatase 2 regulatory subunit Bgamma
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP2R2C, protein phosphatase 2 regulatory subunit Bgamma
  • Synonyms
    B55gamma, B55-GAMMA, IMYPNO, IMYPNO1, PR52, PR55G
  • Links
    NCBI Gene ID: 5522
    UniProt: Q9Y2T4

  • Chr Location
    4p16.1; chr4:6320578-6563799 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotype references
  • All Mutations and Alleles
    14
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    2
  • Radiation induced
    4
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    8 involving Ppp2r2c
  • Incidental Mutations
    Mutagenetix , APF , CvDC
  • Find Mice (IMSR)
    18 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    630
  • Tissues
    20
  • cDNA Data
    37
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029120 Ensembl Gene Model | MGI Sequence Detail 86566 C57BL/6J ±  kb
transcript ENSMUST00000031003 Ensembl | MGI Sequence Detail 4088 Not Applicable  
polypeptide ENSMUSP00000031003 Ensembl | MGI Sequence Detail 447 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013137 serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
    (term hierarchy)
  • InterPro Domains
    IPR000009 Protein phosphatase 2A regulatory subunit PR55
    IPR018067 Protein phosphatase 2A regulatory subunit PR55, conserved site
    IPR001680 WD40 repeat
    IPR036322 WD40-repeat-containing domain superfamily
    IPR015943 WD40/YVTN repeat-like-containing domain superfamily
  • GlyGen
    Q8BG02 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 39
    cDNA 37
    Primer pair 1
    Other 1

    Microarray probesets 6
References
more
  • Summaries
    All 58
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 3
    Phenotypes 23
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:383143 Singh A, et al., Cajal-Retzius fate specification is disrupted by constitutive activation of beta-Catenin in hem progenitors. Development. 2026 Apr 1;153(7):dev205072
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory