Lrrc4c MGI Mouse Gene Detail - MGI:2442636 - leucine rich repeat containing 4C

Symbol

Lrrc4c
Name

leucine rich repeat containing 4C
Synonyms

6430556C10Rik, mKIAA1580, netrin g1 ligand, NGL-1

Feature Type

protein coding gene
IDs

MGI:2442636
NCBI Gene: 241568
Alliance

genome feature page
Transcription Start Sites

21 TSS

Sequence Map

Chr2:96148514-97462011 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 52.30 cM
Mapping Data

1 experiment

SNPs within 2kb

39436 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2442636	protein coding gene	Chr2:96148514-97466871 (+)
129S1/SvImJ	ENSMUSG00200002237	protein coding gene	Chr2:93082163-94401635 (+)
A/J	ENSMUSG00195000651	protein coding gene	Chr2:94349300-94513364 (+)
AKR/J	ENSMUSG00220001587	protein coding gene	Chr2:92985936-94342046 (+)
BALB/cJ	ENSMUSG00180020441	protein coding gene	Chr2:93099350-94399484 (+)
C3H/HeJ	ENSMUSG00175009931	protein coding gene	Chr2:94533344-94697424 (+)
C57BL/6NJ	ENSMUSG00215015906	protein coding gene	Chr2:93187616-94502305 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023999	protein coding gene	Chr2:90201642-91448804 (+)
CAST/EiJ	ENSTCUG00005001355	protein coding gene	Chr2:92550636-93838014 (+)
CBA/J	ENSMUSG00210001970	protein coding gene	Chr2:93377736-94677969 (+)
DBA/2J	ENSMUSG00185005564	protein coding gene	Chr2:93095628-94395858 (+)
FVB/NJ	ENSMUSG00205009828	protein coding gene	Chr2:92343582-93689486 (+)
JF1/MsJ	ENSUMUG00000027072	protein coding gene	Chr2:92906843-94178871 (+)
LP/J	ENSMUSG00230000883	protein coding gene	Chr2:94845943-96146139 (+)
NOD/ShiLtJ	ENSMUSG00190021781	protein coding gene	Chr2:93175653-94477266 (+)
NZO/HlLtJ	ENSMUSG00225008508	protein coding gene	Chr2:102766695-104078390 (+)
PWK/PhJ	ENSLUMG00010024237	protein coding gene	Chr2:92826252-94114969 (+)
SPRET/EiJ	ENSMSPG00010008362	protein coding gene	Chr2:95933593-96142653 (+)
WSB/EiJ	ENSIUOG00005001387	protein coding gene	Chr2:94011747-94175973 (+)

Human Ortholog

LRRC4C, leucine rich repeat containing 4C

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRC4C, leucine rich repeat containing 4C
Synonyms

NGL-1, NGL1
Links

HGNC:29317

NCBI Gene ID: 57689

UniProt: Q9HCJ2
Chr Location

11p12; chr11:40113474-41459773 (-) GRCh38

MGI Vertebrate Homology

Lrrc4c stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: LRRC4C
Gene Tree

Lrrc4c

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

6
Genomic Mutations

4 involving Lrrc4c
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutant mice exhibited an increased mean serum IL-6 response to LPS challenge when compared with controls. No other notable phenotype was detected in a high-througput screen.

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All GO Annotations

39
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

620
Tissues

20
cDNA Data

11
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lrrc4c

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All Sequences

61
RefSeq

18
UniProt

2
CCDS

CCDS16460.1

Ensembl

ENSMUSG00000050587 (Evidence)
NCBI Gene

241568

			Length	Strain/Species	Flank
genomic	ENSMUSG00000050587	Ensembl Gene Model \| MGI Sequence Detail	1313498	C57BL/6J	± kb
transcript	ENSMUST00000059049	Ensembl \| MGI Sequence Detail	3492	Not Applicable
polypeptide	ENSMUSP00000131795	Ensembl \| MGI Sequence Detail	640	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009937 netrin-G1 ligand

(term hierarchy)
InterPro Domains

IPR003599 Immunoglobulin domain subtype

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003598 Immunoglobulin subtype 2

IPR013106 Immunoglobulin V-set domain

IPR001611 Leucine-rich repeat

IPR050541 Leucine-rich repeat and transmembrane domain-containing protein

IPR032675 Leucine-rich repeat domain superfamily

IPR000372 Leucine-rich repeat N-terminal domain

IPR003591 Leucine-rich repeat, typical subtype
GlyGen

Q8C031 5 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (1 site)

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All nucleic 13

cDNA 11

Primer pair 1

Other 1

Microarray probesets 2

Summaries

All 51

Developmental Gene Expression 7

Gene Ontology 9

Phenotypes 16
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:333829 Lopez-Tello J, et al., Characterization of placental endocrine function and fetal brain development in a mouse model of small for gestational age. Front Endocrinol (Lausanne). 2023;14:1116770

TSS for Lrrc4c:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr19006	Chr2:96148096-96148126 (+)	-403 bp
Tssr19007	Chr2:96148128-96148150 (+)	-375 bp
Tssr19008	Chr2:96148165-96148176 (+)	-343 bp
Tssr19009	Chr2:96148280-96148292 (+)	-228 bp
Tssr19010	Chr2:96148359-96148402 (+)	-133 bp
Tssr19011	Chr2:96148418-96148429 (+)	-90 bp
Tssr19012	Chr2:96148704-96148748 (+)	212 bp
Tssr19013	Chr2:96171420-96171437 (+)	22,915 bp
Tssr19014	Chr2:96665123-96665125 (+)	516,610 bp
Tssr19015	Chr2:96955464-96955467 (+)	806,952 bp
Tssr19017	Chr2:97297821-97297850 (+)	1,149,322 bp
Tssr19018	Chr2:97297884-97297904 (+)	1,149,380 bp
Tssr19019	Chr2:97297920-97297931 (+)	1,149,412 bp
Tssr19020	Chr2:97298031-97298044 (+)	1,149,524 bp
Tssr19021	Chr2:97310459-97310465 (+)	1,161,948 bp
Tssr19022	Chr2:97327701-97327703 (+)	1,179,188 bp
Tssr19023	Chr2:97332857-97332861 (+)	1,184,345 bp
Tssr19024	Chr2:97356481-97356485 (+)	1,207,969 bp
Tssr19025	Chr2:97461101-97461113 (+)	1,312,593 bp
Tssr19026	Chr2:97461142-97461163 (+)	1,312,639 bp
Tssr19027	Chr2:97461172-97461181 (+)	1,312,663 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24