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Simc1 Gene Detail
Summary
  • Symbol
    Simc1
  • Name
    SUMO-interacting motifs containing 1
  • Synonyms
    4732471D19Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442599
    NCBI Gene: 319719
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:54651592-54699103 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 28.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442599
 protein coding gene Chr13:54651539-54699103 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020569
 protein coding gene Chr13:53905329-53952567 (+)
A/J MGP_AJ_G0020523
 protein coding gene Chr13:51930789-51976543 (+)
AKR/J MGP_AKRJ_G0020501
 protein coding gene Chr13:53457633-53503918 (+)
BALB/cJ MGP_BALBcJ_G0020519
 protein coding gene Chr13:52159156-52204903 (+)
C3H/HeJ MGP_C3HHeJ_G0020318
 protein coding gene Chr13:53278844-53327575 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020953
 protein coding gene Chr13:55556989-55608783 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018535
 protein coding gene Chr13:49926411-49970522 (+)
CAST/EiJ MGP_CASTEiJ_G0019832
 protein coding gene Chr13:53352171-53406076 (+)
CBA/J MGP_CBAJ_G0020278
 protein coding gene Chr13:57662243-57717951 (+)
DBA/2J MGP_DBA2J_G0020401
 protein coding gene Chr13:51497127-51544659 (+)
FVB/NJ MGP_FVBNJ_G0020380
 protein coding gene Chr13:50945750-50991648 (+)
LP/J MGP_LPJ_G0020477
 protein coding gene Chr13:54179297-54228114 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020409
 protein coding gene Chr13:57162284-57218483 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020996
 protein coding gene Chr13:53048560-53096535 (+)
PWK/PhJ MGP_PWKPhJ_G0019588
 protein coding gene Chr13:51475574-51528689 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019415
 protein coding gene Chr13:51956672-52008269 (+)
WSB/EiJ MGP_WSBEiJ_G0019894
 protein coding gene Chr13:53380710-53429870 (+)



Homology
more
  • Human Ortholog
    SIMC1, SUMO interacting motifs containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIMC1, SUMO interacting motifs containing 1
  • Synonyms
    C5orf25, OOMA1, PLEIAD
  • Links
    NCBI Gene ID: 375484
    neXtProt AC: NX_Q8NDZ2
    UniProt: Q8NDZ2

  • Chr Location
    5q35.2; chr5:176238367-176345991 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Simc1
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    58 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    69
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043183 Ensembl Gene Model | MGI Sequence Detail 47512 C57BL/6J ±  kb
transcript ENSMUST00000121401 Ensembl | MGI Sequence Detail 4819 Not Applicable  
polypeptide ENSMUSP00000113676 Ensembl | MGI Sequence Detail 1354 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 69
    cDNA 69

    Microarray probesets 5
References
more
  • Summaries
    All 33
    Diseases 1
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:190741 Migdalska AM, et al., Generation of the Sotos syndrome deletion in mice. Mamm Genome. 2012 Dec;23(11-12):749-57
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory