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Irf2bpl Gene Detail
Summary
  • Symbol
    Irf2bpl
  • Name
    interferon regulatory factor 2 binding protein-like
  • Synonyms
    6430527G18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442463
    NCBI Gene: 238330
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:86927475-86931572 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 41.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    18 from dbSNP Build 142
  • Strain Annotations
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442463
 protein coding gene Chr12:86927475-86931588 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0019931
 protein coding gene Chr12:84423137-84427308 (-)
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0020362
 protein coding gene Chr12:90279078-90287941 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017980
 protein coding gene Chr12:81304982-81309086 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0019688
 protein coding gene Chr12:93758587-93763037 (-)
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0019030
 protein coding gene Chr12:78463267-78467296 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0019319
 protein coding gene Chr12:87076972-87080351 (-)



Homology
more
  • Human Ortholog
    IRF2BPL, interferon regulatory factor 2 binding protein like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRF2BPL, interferon regulatory factor 2 binding protein like
  • Synonyms
    C14orf4, EAP1, NEDAMSS
  • Links
    NCBI Gene ID: 64207
    neXtProt AC: NX_Q9H1B7
    UniProt: Q9H1B7

  • Chr Location
    14q24.3; chr14:77024543-77028708 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IRF2BPL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    7
  • Targeted
    1
  • Genomic Mutations
    1 involving Irf2bpl
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    29 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    127
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034168 Ensembl Gene Model | MGI Sequence Detail 4098 C57BL/6J ±  kb
transcript ENSMUST00000038422 Ensembl | MGI Sequence Detail 4098 Not Applicable  
polypeptide ENSMUSP00000041070 Ensembl | MGI Sequence Detail 775 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000006864 enhanced at puberty protein 1
    (term hierarchy)
  • EC
    2.3.2.27
  • InterPro Domains
    IPR044882 Interferon regulatory factor 2-binding protein 1/2, C3HC4-type RING finger superfamily
    IPR022750 Interferon regulatory factor 2-binding protein 1 & 2, zinc finger
Molecular
Reagents
less
  • All nucleic 127
    cDNA 127

    Microarray probesets 8
References
more
  • Summaries
    All 33
    Gene Ontology 7
    Phenotypes 8
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:237827 Gineste C, et al., In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Neuromuscul Disord. 2013 Apr;23(4):357-69
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory