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Tmx3 Gene Detail
Summary
  • Symbol
    Tmx3
  • Name
    thioredoxin-related transmembrane protein 3
  • Synonyms
    6430411B10Rik, A730024F05Rik, mKIAA1830, Txndc10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442418
    NCBI Gene: 67988
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:90528336-90561391 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 59.37 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    528 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442418
 protein coding gene Chr18:90528278-90561391 (+)
129S1/SvImJ ENSMUSG00200015261
 protein coding gene Chr18:87880729-87913840 (+)
A/J ENSMUSG00195001301
 protein coding gene Chr18:87802849-87835964 (+)
AKR/J no annotation
BALB/cJ ENSMUSG00180002497
 protein coding gene Chr18:88404140-88437255 (+)
C3H/HeJ ENSMUSG00175018340
 protein coding gene Chr18:87915629-87948742 (+)
C57BL/6NJ ENSMUSG00215004231
 protein coding gene Chr18:87391933-87425049 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022462
 protein coding gene Chr18:86356169-86388423 (+)
CAST/EiJ ENSTCUG00005005363
 protein coding gene Chr18:86758769-86791838 (+)
CBA/J ENSMUSG00210017784
 protein coding gene Chr18:87867141-87900255 (+)
DBA/2J ENSMUSG00185004235
 protein coding gene Chr18:87754370-87787483 (+)
FVB/NJ ENSMUSG00205012866
 protein coding gene Chr18:87215330-87248444 (+)
JF1/MsJ ENSUMUG00000017683
 protein coding gene Chr18:87605606-87638757 (+)
LP/J ENSMUSG00230015791
 protein coding gene Chr18:89939012-89972123 (+)
NOD/ShiLtJ ENSMUSG00190003348
 protein coding gene Chr18:87602941-87636054 (+)
NZO/HlLtJ ENSMUSG00225023283
 protein coding gene Chr18:89766554-89799662 (+)
PWK/PhJ ENSLUMG00010004002
 protein coding gene Chr18:88039564-88072682 (+)
SPRET/EiJ ENSMSPG00010001248
 protein coding gene Chr18:88564988-88603848 (+)
WSB/EiJ ENSIUOG00005015900
 protein coding gene Chr18:87269237-87302352 (+)



Homology
more
  • Human Ortholog
    TMX3, thioredoxin related transmembrane protein 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMX3, thioredoxin related transmembrane protein 3
  • Synonyms
    PDIA13, TXNDC10
  • Links
    NCBI Gene ID: 54495
    UniProt: Q96JJ7

  • Chr Location
    18q22.1; chr18:68673688-68715147 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from multigenic genotypes
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    609
  • Tissues
    10
  • cDNA Data
    17
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67988 NCBI Gene Model | MGI Sequence Detail 33056 C57BL/6J ±  kb
transcript NM_198295 RefSeq | MGI Sequence Detail 4553 C57BL/6  
polypeptide Q8BXZ1 UniProt | EBI | MGI Sequence Detail 456 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Primer pair 1

    Microarray probesets 10
Other
Accession IDs
less
MGI:1915238, MGI:2147338
References
more
  • Summaries
    All 43
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:45709 Melloy PG, et al., No turning, a mouse mutation causing left-right and axial patterning defects. Dev Biol. 1998 Jan 1;193(1):77-89
  • Latest
    J:362983 Chen F, et al., Differential transport pathways of saturated and unsaturated fatty acid esters in male mouse hepatocytes. Nat Commun. 2025 Feb 4;16(1):1344
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory