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Usp28 Gene Detail
Summary
  • Symbol
    Usp28
  • Name
    ubiquitin specific peptidase 28
  • Synonyms
    9830148O20Rik, mKIAA1515
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442293
    NCBI Gene: 235323
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:48896675-48953817 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 26.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1358 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442293
 protein coding gene Chr9:48896577-48953817 (+)
129S1/SvImJ ENSMUSG00200018033
 protein coding gene Chr9:46063089-46120232 (+)
A/J ENSMUSG00195023235
 protein coding gene Chr9:45744297-45801812 (+)
AKR/J ENSMUSG00220033053
 protein coding gene Chr9:45835656-45892795 (+)
BALB/cJ ENSMUSG00180027564
 protein coding gene Chr9:45855663-45913179 (+)
C3H/HeJ ENSMUSG00175012698
 protein coding gene Chr9:45867830-45925344 (+)
C57BL/6NJ ENSMUSG00215029968
 protein coding gene Chr9:45820104-45877235 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032173
 protein coding gene Chr9:45857450-45915204 (+)
CAST/EiJ ENSTCUG00005013717
 protein coding gene Chr9:45794469-45851416 (+)
CBA/J ENSMUSG00210016173
 protein coding gene Chr9:45944581-46001705 (+)
DBA/2J ENSMUSG00185010261
 protein coding gene Chr9:45982099-46039609 (+)
FVB/NJ ENSMUSG00205030147
 protein coding gene Chr9:46219687-46275027 (+)
JF1/MsJ ENSUMUG00000025361
 protein coding gene Chr9:46040588-46098139 (+)
LP/J ENSMUSG00230035995
 protein coding gene Chr9:46279680-46336817 (+)
NOD/ShiLtJ ENSMUSG00190017550
 protein coding gene Chr9:46069207-46126279 (+)
NZO/HlLtJ ENSMUSG00225043686
 protein coding gene Chr9:46241181-46298321 (+)
PWK/PhJ ENSLUMG00010020572
 protein coding gene Chr9:46005651-46062789 (+)
SPRET/EiJ ENSMSPG00010010800
 protein coding gene Chr9:46776260-46833717 (+)
WSB/EiJ ENSIUOG00005017223
 protein coding gene Chr9:45474098-45531289 (+)



Homology
more
  • Human Ortholog
    USP28, ubiquitin specific peptidase 28
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP28, ubiquitin specific peptidase 28
  • Links
    NCBI Gene ID: 57646
    UniProt: Q96RU2

  • Chr Location
    11q23.2; chr11:113797870-113875590 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and fertile and exhibit slightly decreased spleen weight and splenocyte number but show neither major signaling defects in DNA damage response nor developmental defects indicative of impaired double-strand break metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    698
  • Tissues
    23
  • cDNA Data
    124
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032267 Ensembl Gene Model | MGI Sequence Detail 57143 C57BL/6J ±  kb
    transcript ENSMUST00000047349 Ensembl | MGI Sequence Detail 4133 Not Applicable  
    polypeptide ENSMUSP00000047467 Ensembl | MGI Sequence Detail 1051 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000017166 ubiquitin carboxyl-terminal hydrolase 28
      (term hierarchy)
    • EC
      3.4.19.12
    • InterPro Domains
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR054109 UBA-like domain
      IPR009060 UBA-like superfamily
      IPR044635 Ubiquitin carboxyl-terminal hydrolase 14-like
      IPR054108 Ubiquitin carboxyl-terminal hydrolase 25/28, UIM
      IPR050164 Ubiquitin carboxyl-terminal hydrolases
      IPR059996 Ubiquitin-specific protease 28, C-terminal domain
      IPR018200 Ubiquitin specific protease, conserved site
      IPR028889 Ubiquitin specific protease USP, catalytic domain
    Molecular
    Reagents
    less
    • All nucleic 128
      cDNA 124
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143214
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 23
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:347621 Grzonka M, et al., Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells. Elife. 2024 Feb 26;13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory