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Cgas Gene Detail
Summary
  • Symbol
    Cgas
  • Name
    cyclic GMP-AMP synthase
  • Synonyms
    E330016A19Rik, Mb21d1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442261
    NCBI Gene: 214763
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:78337808-78350519 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 43.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    371 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442261
 protein coding gene Chr9:78337800-78350519 (-)
129S1/SvImJ ENSMUSG00200018642
 protein coding gene Chr9:75488823-75501573 (-)
A/J ENSMUSG00195009778
 protein coding gene Chr9:75272948-75285657 (-)
AKR/J ENSMUSG00220014667
 protein coding gene Chr9:75379279-75391988 (-)
BALB/cJ ENSMUSG00180016874
 protein coding gene Chr9:75386482-75399191 (-)
C3H/HeJ ENSMUSG00175011491
 protein coding gene Chr9:75445338-75458046 (-)
C57BL/6NJ ENSMUSG00215007532
 protein coding gene Chr9:75324598-75337310 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032468
 protein coding gene Chr9:75441587-75453970 (-)
CAST/EiJ ENSTCUG00005008973
 protein coding gene Chr9:75024451-75037172 (-)
CBA/J ENSMUSG00210013183
 protein coding gene Chr9:75478258-75490966 (-)
DBA/2J ENSMUSG00185006487
 protein coding gene Chr9:75506573-75519282 (-)
FVB/NJ ENSMUSG00205025856
 protein coding gene Chr9:75667280-75679989 (-)
JF1/MsJ ENSUMUG00000029864
 protein coding gene Chr9:75414886-75427631 (-)
LP/J ENSMUSG00230024803
 protein coding gene Chr9:75640418-75653166 (-)
NOD/ShiLtJ ENSMUSG00190024832
 protein coding gene Chr9:75582651-75595359 (-)
NZO/HlLtJ ENSMUSG00225024758
 protein coding gene Chr9:75804523-75817231 (-)
PWK/PhJ ENSLUMG00010015280
 protein coding gene Chr9:75347917-75360658 (-)
SPRET/EiJ ENSMSPG00010003939
 protein coding gene Chr9:76575286-76588122 (-)
WSB/EiJ ENSIUOG00005023542
 protein coding gene Chr9:74911218-74923925 (-)



Homology
more
  • Human Ortholog
    CGAS, cyclic GMP-AMP synthase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CGAS, cyclic GMP-AMP synthase
  • Synonyms
    C6orf150, D4, h-cGAS, MB21D1
  • Links
    NCBI Gene ID: 115004
    UniProt: Q8N884

  • Chr Location
    6q13; chr6:73413515-73461726 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 5 genetic backgrounds
    2 phenotypes from multigenic genotypes
    224 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased susceptibility to viral infection and abnormal innate immunity. Conditional expression of the p.R241E mutation in microglia leads to reduced spatial learning owing to hippocampal neuron degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    128
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    603
  • Tissues
    3
  • cDNA Data
    22
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032344 Ensembl Gene Model | MGI Sequence Detail 12712 C57BL/6J ±  kb
    transcript ENSMUST00000070742 Ensembl | MGI Sequence Detail 4049 Not Applicable  
    polypeptide ENSMUSP00000063331 Ensembl | MGI Sequence Detail 507 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 23

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:6188849
    References
    more
    • Summaries
      All 393
      Developmental Gene Expression 4
      Gene Ontology 34
      Phenotypes 224
    • Earliest
      J:12013 Russell LB, Definition of functional units in a small chromosomal segment of the mouse and its use in interpreting the nature of radiation-induced mutations. Mutat Res. 1971 Jan;11(1):107-23
    • Latest
      J:390290 Regina A, et al., Cardiolipin preserves T(reg) metabolic fitness and immune homeostasis in the gut. Nat Metab. 2026 Jun;8(6):1368-1389
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory