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Taf5 Gene Detail
Summary
  • Symbol
    Taf5
  • Name
    TATA-box binding protein associated factor 5
  • Synonyms
    6330528C20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442144
    NCBI Gene: 226182
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:47056187-47071918 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 39.19 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    467 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442144
 protein coding gene Chr19:47056185-47071918 (+)
129S1/SvImJ ENSMUSG00200020320
 protein coding gene Chr19:43762510-43778254 (+)
A/J ENSMUSG00195016555
 protein coding gene Chr19:43893070-43908870 (+)
AKR/J ENSMUSG00220018563
 protein coding gene Chr19:43698223-43714020 (+)
BALB/cJ ENSMUSG00180017048
 protein coding gene Chr19:44145129-44160911 (+)
C3H/HeJ ENSMUSG00175005971
 protein coding gene Chr19:43691164-43706959 (+)
C57BL/6NJ ENSMUSG00215004653
 protein coding gene Chr19:43754927-43770665 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023049
 protein coding gene Chr19:43746362-43761551 (+)
CAST/EiJ ENSTCUG00005015288
 protein coding gene Chr19:43352267-43368320 (+)
CBA/J ENSMUSG00210018016
 protein coding gene Chr19:43770662-43786453 (+)
DBA/2J ENSMUSG00185008360
 protein coding gene Chr19:44268503-44284280 (+)
FVB/NJ ENSMUSG00205029229
 protein coding gene Chr19:43186473-43202257 (+)
JF1/MsJ ENSUMUG00000028256
 protein coding gene Chr19:44427925-44443800 (+)
LP/J ENSMUSG00230023631
 protein coding gene Chr19:45032100-45047837 (+)
NOD/ShiLtJ ENSMUSG00190004915
 protein coding gene Chr19:43634992-43650771 (+)
NZO/HlLtJ ENSMUSG00225043863
 protein coding gene Chr19:48627858-48643641 (+)
PWK/PhJ ENSLUMG00010001097
 protein coding gene Chr19:43593771-43609641 (+)
SPRET/EiJ ENSMSPG00010007295
 protein coding gene Chr19:43327081-43342678 (+)
WSB/EiJ ENSIUOG00005005876
 protein coding gene Chr19:43139723-43155590 (+)



Homology
more
  • Human Ortholog
    TAF5, TATA-box binding protein associated factor 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAF5, TATA-box binding protein associated factor 5
  • Synonyms
    TAF2D, TAF(II)100, TAFII-100, TAFII100
  • Links
    NCBI Gene ID: 6877
    UniProt: Q15542

  • Chr Location
    10q24.33; chr10:103367964-103389065 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele arrest before progressing to an egg-cylinder stage and show empty deciduae, failure of embryo implantation, aberrant lineage specification within the inner cell mass, and peri-implantation lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    711
  • Tissues
    100
  • cDNA Data
    10
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 226182 NCBI Gene Model | MGI Sequence Detail 15732 C57BL/6J ±  kb
    transcript NM_177342 RefSeq | MGI Sequence Detail 3258 C57BL/6  
    polypeptide Q8C092 UniProt | EBI | MGI Sequence Detail 801 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 10
      Primer pair 5
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2147674
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 10
      Gene Ontology 12
      Phenotypes 12
    • Earliest
      J:25214 LeDouarin B, et al., The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J. 1995 May 1;14(9):2020-33
    • Latest
      J:348275 He XD, et al., TATA-binding associated factors have distinct roles during early mammalian development. Dev Biol. 2024 Jul;511:53-62
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory