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Serpine3 Gene Detail
Summary
  • Symbol
    Serpine3
  • Name
    serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
  • Synonyms
    E130113E03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2442020
    NCBI Gene: 319433
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:62901116-62929692 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.23 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    722 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2442020
 protein coding gene Chr14:62900743-62929692 (+)
129S1/SvImJ ENSMUSG00200030160
 protein coding gene Chr14:51501445-51529956 (+)
A/J ENSMUSG00195029675
 protein coding gene Chr14:51673118-51701675 (+)
AKR/J ENSMUSG00220028074
 protein coding gene Chr14:51020469-51049067 (+)
BALB/cJ ENSMUSG00180051110
 protein coding gene Chr14:51295033-51323594 (+)
C3H/HeJ ENSMUSG00175035285
 protein coding gene Chr14:53037267-53065772 (+)
C57BL/6NJ ENSMUSG00215045217
 protein coding gene Chr14:51228356-51256932 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019392
 protein coding gene Chr14:53801402-53827211 (+)
CAST/EiJ ENSTCUG00005038869
 protein coding gene Chr14:52960858-52989405 (+)
CBA/J ENSMUSG00210037331
 protein coding gene Chr14:51661012-51689582 (+)
DBA/2J ENSMUSG00185030791
 protein coding gene Chr14:56835065-56863572 (+)
FVB/NJ ENSMUSG00205023538
 protein coding gene Chr14:51180106-51208679 (+)
JF1/MsJ ENSUMUG00000040887
 protein coding gene Chr14:68025545-68054007 (+)
LP/J ENSMUSG00230033351
 protein coding gene Chr14:68864648-68893157 (+)
NOD/ShiLtJ ENSMUSG00190030965
 protein coding gene Chr14:51457395-51485949 (+)
NZO/HlLtJ ENSMUSG00225044732
 protein coding gene Chr14:59197900-59226472 (+)
PWK/PhJ ENSLUMG00010045791
 protein coding gene Chr14:50909971-50940192 (+)
SPRET/EiJ ENSMSPG00010029999
 protein coding gene Chr14:54382243-54411075 (+)
WSB/EiJ ENSIUOG00005037590
 protein coding gene Chr14:50908649-50937153 (+)



Homology
more
  • Human Ortholog
    SERPINE3, serpin family E member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPINE3, serpin family E member 3
  • Links
    NCBI Gene ID: 647174
    UniProt: A8MV23

  • Chr Location
    13q14.3; chr13:51335773-51364735 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    5
  • Targeted
    2
  • Genomic Mutations
    1 involving Serpine3
  • Find Mice (IMSR)
    20 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000091155 Ensembl Gene Model | MGI Sequence Detail 28577 C57BL/6J ±  kb
transcript ENSMUST00000171692 Ensembl | MGI Sequence Detail 1402 Not Applicable  
polypeptide ENSMUSP00000125769 Ensembl | MGI Sequence Detail 401 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1

    Microarray probesets 1
References
more
  • Summaries
    All 20
    Gene Ontology 2
    Phenotypes 7
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:382396 Indrischek H, et al., Vision-related convergent gene losses reveal SERPINE3's unknown role in the eye. Elife. 2022 Jun 21;11:e77999
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory