About   Help   FAQ
Npsr1 Gene Detail
Summary
  • Symbol
    Npsr1
  • Name
    neuropeptide S receptor 1
  • Synonyms
    9330128H10Rik, Gpr154, PGR14, VRR1
Location &
Maps
more
  • Sequence Map
    Chr9:24009292-24227694 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 9.99 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    6288 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2441738
 protein coding gene Chr9:24009212-24229151 (+)
129S1/SvImJ ENSMUSG00200007297
 protein coding gene Chr9:20986023-21204570 (+)
A/J ENSMUSG00195005562
 protein coding gene Chr9:20802352-21020921 (+)
AKR/J ENSMUSG00220010315
 protein coding gene Chr9:20802773-21021362 (+)
BALB/cJ ENSMUSG00180006416
 protein coding gene Chr9:20936555-21155126 (+)
C3H/HeJ ENSMUSG00175019417
 protein coding gene Chr9:20913016-21131592 (+)
C57BL/6NJ ENSMUSG00215006670
 protein coding gene Chr9:20899456-21116875 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031911
 protein coding gene Chr9:20026107-20237910 (+)
CAST/EiJ ENSTCUG00005018214
 protein coding gene Chr9:20902366-21115747 (+)
CBA/J ENSMUSG00210022070
 protein coding gene Chr9:20907067-21138314 (+)
DBA/2J ENSMUSG00185002085
 protein coding gene Chr9:20995179-21213769 (+)
FVB/NJ ENSMUSG00205004397
 protein coding gene Chr9:21237008-21468326 (+)
JF1/MsJ ENSUMUG00000011630
 protein coding gene Chr9:21107350-21311986 (+)
LP/J ENSMUSG00230004331
 protein coding gene Chr9:21395091-21613658 (+)
NOD/ShiLtJ ENSMUSG00190006021
 protein coding gene Chr9:20947055-21158760 (+)
NZO/HlLtJ ENSMUSG00225014353
 protein coding gene Chr9:21357204-21588482 (+)
PWK/PhJ ENSLUMG00010009118
 protein coding gene Chr9:20988496-21194527 (+)
SPRET/EiJ ENSMSPG00010002049
 protein coding gene Chr9:21259281-21465516 (+)
WSB/EiJ ENSIUOG00005015712
 protein coding gene Chr9:20467744-20678799 (+)



Homology
more
  • Human Ortholog
    NPSR1, neuropeptide S receptor 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPSR1, neuropeptide S receptor 1
  • Synonyms
    ASRT2, FNSS3, GPR154, GPRA, NPSR, PGR14, VRR1
  • Links
    NCBI Gene ID: 387129
    UniProt: Q6W5P4

  • Chr Location
    7p14.3; chr7:34658218-34878332 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human NPSR1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 4 alleles in 5 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased airway resistance when treated with high concentrations of U-46619. Heterozygosity for p.Y206H mutation leads to shorter sleep periods without sleep deprivation-related memory phenotypes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    804
  • Tissues
    35
  • cDNA Data
    8
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043659 Ensembl Gene Model | MGI Sequence Detail 218403 C57BL/6J ±  kb
transcript ENSMUST00000059650 Ensembl | MGI Sequence Detail 3791 Not Applicable  
polypeptide ENSMUSP00000056432 Ensembl | MGI Sequence Detail 371 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 1
References
more
  • Summaries
    All 56
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 26
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory