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Wwc1 Gene Detail
Summary
  • Symbol
    Wwc1
  • Name
    WW, C2 and coiled-coil domain containing 1
  • Synonyms
    Kibra, MGC:47054
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388637
    NCBI Gene: 211652
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:35729227-35871354 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 21.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4257 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2388637
 protein coding gene Chr11:35729226-35871354 (-)
129S1/SvImJ ENSMUSG00200006868
 protein coding gene Chr11:32783848-32926609 (-)
A/J ENSMUSG00195006827
 protein coding gene Chr11:32708877-32851225 (-)
AKR/J ENSMUSG00220003102
 protein coding gene Chr11:32894531-33036868 (-)
BALB/cJ ENSMUSG00180001665
 protein coding gene Chr11:32709007-32851341 (-)
C3H/HeJ ENSMUSG00175003503
 protein coding gene Chr11:32678702-32821021 (-)
C57BL/6NJ ENSMUSG00215009767
 protein coding gene Chr11:32632917-32775177 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016209
 protein coding gene Chr11:31418773-31560458 (-)
CAST/EiJ ENSTCUG00005012880
 protein coding gene Chr11:32539979-32685332 (-)
CBA/J ENSMUSG00210006615
 protein coding gene Chr11:32564935-32707245 (-)
DBA/2J ENSMUSG00185010009
 protein coding gene Chr11:32758031-32900335 (-)
FVB/NJ ENSMUSG00205011248
 protein coding gene Chr11:32804420-32946639 (-)
JF1/MsJ ENSUMUG00000004875
 protein coding gene Chr11:33076157-33218858 (-)
LP/J ENSMUSG00230003045
 protein coding gene Chr11:33929115-34071436 (-)
NOD/ShiLtJ ENSMUSG00190007227
 protein coding gene Chr11:32825997-32968109 (-)
NZO/HlLtJ ENSMUSG00225030404
 protein coding gene Chr11:35869034-36011684 (-)
PWK/PhJ ENSLUMG00010007185
 protein coding gene Chr11:32646869-32788626 (-)
SPRET/EiJ ENSMSPG00010002248
 protein coding gene Chr11:33026145-33168478 (-)
WSB/EiJ ENSIUOG00005002021
 protein coding gene Chr11:32731577-32872474 (-)



Homology
more
  • Human Ortholog
    WWC1, WW and C2 domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WWC1, WW and C2 domain containing 1
  • Synonyms
    HBEBP3, HBEBP36, KIBRA, MEMRYQTL, PPP1R168
  • Links
    NCBI Gene ID: 23286
    UniProt: Q8IX03

  • Chr Location
    5q34; chr5:168291563-168472303 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired adult synaptic plasticity and fear-based conditioning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    58
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    628
  • Tissues
    21
  • cDNA Data
    10
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000018849 Ensembl Gene Model | MGI Sequence Detail 142128 C57BL/6J ±  kb
transcript ENSMUST00000018993 Ensembl | MGI Sequence Detail 4531 Not Applicable  
polypeptide ENSMUSP00000018993 Ensembl | MGI Sequence Detail 1104 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 10
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGI:2143978, MGI:2144380
References
more
  • Summaries
    All 74
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 31
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:361134 Wang X, et al., WWC proteins-mediated compensatory mechanism restricts schwannomatosis driven by NF2 loss of function. Sci Adv. 2025 Jan 24;11(4):eadp4765
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory