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Ppp2r5b Gene Detail
Summary
  • Symbol
    Ppp2r5b
  • Name
    protein phosphatase 2, regulatory subunit B', beta
  • Synonyms
    B'beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:2388480
    NCBI Gene: 225849
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:6277795-6285902 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 4.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    50 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2388480
 protein coding gene Chr19:6277795-6286294 (-)
129S1/SvImJ ENSMUSG00200043620
 protein coding gene Chr19:3040229-3048336 (-)
A/J ENSMUSG00195049347
 protein coding gene Chr19:3448023-3456130 (-)
AKR/J ENSMUSG00220049469
 protein coding gene Chr19:3214026-3222133 (-)
BALB/cJ ENSMUSG00180042371
 protein coding gene Chr19:3815608-3823715 (-)
C3H/HeJ ENSMUSG00175011457
 protein coding gene Chr19:3065771-3073878 (-)
C57BL/6NJ ENSMUSG00215044896
 protein coding gene Chr19:3278575-3286682 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022601
 protein coding gene Chr19:3012658-3020763 (-)
CAST/EiJ ENSTCUG00005042864
 protein coding gene Chr19:3198540-3206674 (-)
CBA/J ENSMUSG00210040947
 protein coding gene Chr19:3068535-3076642 (-)
DBA/2J ENSMUSG00185044823
 protein coding gene Chr19:3445011-3453118 (-)
FVB/NJ ENSMUSG00205049838
 protein coding gene Chr19:3446945-3455051 (-)
JF1/MsJ ENSUMUG00000013955
 protein coding gene Chr19:3414407-3422515 (-)
LP/J ENSMUSG00230053028
 protein coding gene Chr19:4347096-4355203 (-)
NOD/ShiLtJ ENSMUSG00190024091
 protein coding gene Chr19:2975344-2983451 (-)
NZO/HlLtJ ENSMUSG00225025500
 protein coding gene Chr19:8055908-8064015 (-)
PWK/PhJ ENSLUMG00010004066
 protein coding gene Chr19:3180914-3189022 (-)
SPRET/EiJ ENSMSPG00010047737
 protein coding gene Chr19:3176147-3183530 (-)
WSB/EiJ ENSIUOG00005040804
 protein coding gene Chr19:3088533-3096640 (-)



Homology
more
  • Human Ortholog
    PPP2R5B, protein phosphatase 2 regulatory subunit B'beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPP2R5B, protein phosphatase 2 regulatory subunit B'beta
  • Synonyms
    B56B, B56beta, PR61B
  • Links
    NCBI Gene ID: 5526
    UniProt: Q15173

  • Chr Location
    11q13.1; chr11:64917553-64934480 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    7 phenotype references
Homozygous null mice are viable and show no overt developmental defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    763
  • Tissues
    49
  • cDNA Data
    9
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024777 Ensembl Gene Model | MGI Sequence Detail 8108 C57BL/6J ±  kb
transcript ENSMUST00000025695 Ensembl | MGI Sequence Detail 2742 Not Applicable  
polypeptide ENSMUSP00000025695 Ensembl | MGI Sequence Detail 497 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 11
    cDNA 10
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2446182
References
more
  • Summaries
    All 41
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:348684 Dyson JJ, et al., Growth arrest of PPP2R5C and PPP2R5D double knockout mice indicates a genetic interaction and conserved function for these PP2A B subunits. FASEB Bioadv. 2022 Apr;4(4):273-282
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory