About   Help   FAQ
Adipoqtm1Chan
Targeted Allele Detail
Summary
Symbol: Adipoqtm1Chan
Name: adiponectin, C1Q and collagen domain containing; targeted mutation 1, Lawrence Chan
MGI ID: MGI:2388007
Synonyms: Ad-, Adipo-, ADN-
Gene: Adipoq  Location: Chr16:22965286-22976718 bp, + strand  Genetic Position: Chr16, 13.96 cM, cytoband B3-B4
Alliance: Adipoqtm1Chan page
A basal-like subtype of mammary tumors in Adipoqtm1Chan/Adipoq+ Tg(MMTV-PyVT)634Mul/0 mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79122
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced by a floxed neo cassette inserted by homologous recombination. Transcript was undetected in adipose tissue by Northern blot analysis of homozygous mutant mice. The lack of immunoreactivity by Western blot analysis using a carboxy terminal antibody indicated an absence of normal and truncated protein. (J:79122)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Adipoqtm1Chan
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adipoq Mutation:  40 strains or lines available
References
Original:  J:79122 Ma K, et al., Increased beta -oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem. 2002 Sep 20;277(38):34658-61
All:  100 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory