About   Help   FAQ
Rasgrp4 Gene Detail
Summary
  • Symbol
    Rasgrp4
  • Name
    RAS guanyl releasing protein 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2386851
    NCBI Gene: 233046
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28834358-28853386 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 16.94 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    164 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2386851
 protein coding gene Chr7:28834276-28853386 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031971
 protein coding gene Chr7:28040930-28061335 (+)
A/J MGP_AJ_G0031949
 protein coding gene Chr7:27299256-27318361 (+)
AKR/J MGP_AKRJ_G0031881
 protein coding gene Chr7:28000828-28019683 (+)
BALB/cJ MGP_BALBcJ_G0031956
 protein coding gene Chr7:27463130-27486449 (+)
C3H/HeJ MGP_C3HHeJ_G0031675
 protein coding gene Chr7:28405021-28424648 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032420
 protein coding gene Chr7:28919733-28943342 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029472
 protein coding gene Chr7:28357815-28378720 (+)
CAST/EiJ MGP_CASTEiJ_G0031010
 protein coding gene Chr7:21705437-21726269 (+)
CBA/J MGP_CBAJ_G0031641
 protein coding gene Chr7:30277052-30299112 (+)
DBA/2J MGP_DBA2J_G0031793
 protein coding gene Chr7:27039066-27058107 (+)
FVB/NJ MGP_FVBNJ_G0031750
 protein coding gene Chr7:27131755-27151693 (+)
LP/J MGP_LPJ_G0031873
 protein coding gene Chr7:28332161-28352614 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031786
 protein coding gene Chr7:29657290-29678018 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032450
 protein coding gene Chr7:27493822-27513272 (+)
PWK/PhJ MGP_PWKPhJ_G0030735
 protein coding gene Chr7:22083216-22103715 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030568
 protein coding gene Chr7:18511855-18530261 (+)
WSB/EiJ MGP_WSBEiJ_G0031119
 protein coding gene Chr7:27860855-27881513 (+)



Homology
more
  • Human Ortholog
    RASGRP4, RAS guanyl releasing protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASGRP4, RAS guanyl releasing protein 4
  • Links
    NCBI Gene ID: 115727
    neXtProt AC: NX_Q8TDF6
    UniProt: Q8TDF6

  • Chr Location
    19q13.2; chr19:38409051-38426305 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 4 alleles in 4 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired neutrophil reactive oxygen species production and chemotaxis in vitro. Mice homozygous for another knock-out allele exhibit decreased susceptibility to induced colitis and arthritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    16
  • cDNA Data
    13
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 233046 NCBI Gene Model | MGI Sequence Detail 19029 C57BL/6J ±  kb
    transcript NM_001174155 RefSeq | MGI Sequence Detail 4636 ZRU/MplStud  
    polypeptide Q8BTM9 UniProt | EBI | MGI Sequence Detail 673 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000013761 RAS guanyl-releasing protein 4
      (term hierarchy)
    • InterPro Domains
      IPR046349 C1-like domain superfamily
      IPR020454 Diacylglycerol/phorbol-ester binding
      IPR011992 EF-hand domain pair
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
      IPR023578 Ras guanine nucleotide exchange factor domain superfamily
      IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
      IPR008937 Ras-like guanine nucleotide exchange factor
      IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 13
      Primer pair 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:77824 Yang Y, et al., RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function. J Biol Chem. 2002 Jul 12;277(28):25756-74
    • Latest
      J:280858 Suire S, et al., Frontline Science: TNF-alpha and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-gamma, and neutrophil proinflammatory responses. J Leukoc Biol. 2019 Oct;106(4):815-822
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory