Mpp4 MGI Mouse Gene Detail - MGI:2386681 - membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)

Symbol

Mpp4
Name

membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
Synonyms

DLG6

Feature Type

protein coding gene
IDs

MGI:2386681
NCBI Gene: 227157
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:59160094-59202548 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 29.20 cM
Mapping Data

1 experiment

SNPs within 2kb

1394 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2386681	protein coding gene	Chr1:59160094-59202548 (-)
129S1/SvImJ	ENSMUSG00200018547	protein coding gene	Chr1:56660440-56702904 (-)
A/J	ENSMUSG00195027452	protein coding gene	Chr1:56198176-56240635 (-)
AKR/J	ENSMUSG00220039212	protein coding gene	Chr1:56288365-56330819 (-)
BALB/cJ	ENSMUSG00180013888	protein coding gene	Chr1:56439802-56482261 (-)
C3H/HeJ	ENSMUSG00175000972	protein coding gene	Chr1:56575628-56618088 (-)
C57BL/6NJ	ENSMUSG00215022426	protein coding gene	Chr1:56507487-56549950 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014175	protein coding gene	Chr1:52838801-52883283 (-)
CAST/EiJ	ENSTCUG00005012756	protein coding gene	Chr1:56350382-56392635 (-)
CBA/J	ENSMUSG00210033008	protein coding gene	Chr1:56260644-56303088 (-)
DBA/2J	ENSMUSG00185036746	protein coding gene	Chr1:57380361-57422806 (-)
FVB/NJ	ENSMUSG00205015606	protein coding gene	Chr1:56221482-56263938 (-)
JF1/MsJ	ENSUMUG00000037577	protein coding gene	Chr1:56343044-56385463 (-)
LP/J	ENSMUSG00230026341	protein coding gene	Chr1:57380970-57423424 (-)
NOD/ShiLtJ	ENSMUSG00190025366	protein coding gene	Chr1:56420884-56463350 (-)
NZO/HlLtJ	ENSMUSG00225007686	protein coding gene	Chr1:60587832-60630265 (-)
PWK/PhJ	ENSLUMG00010024046	protein coding gene	Chr1:55861241-55903571 (-)
SPRET/EiJ	ENSMSPG00010024029	protein coding gene	Chr1:57803558-57846282 (-)
WSB/EiJ	ENSIUOG00005020348	protein coding gene	Chr1:56045424-56087915 (-)

Human Ortholog

MPP4, MAGUK p55 scaffold protein 4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MPP4, MAGUK p55 scaffold protein 4
Synonyms

ALS2CR5, DLG6
Links

HGNC:13680

NCBI Gene ID: 58538

UniProt: Q96JB8
Chr Location

2q33.1; chr2:201644870-201698694 (-) GRCh38

MGI Vertebrate Homology

Mpp4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MPP4
Gene Tree

Mpp4

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Gene trapped

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Mpp4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

41 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for mutations display sporadic photorecptor displacement. Correct protein localization at the presynaptic photoreceptor membrane.

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All GO Annotations

23
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

638
Tissues

24
cDNA Data

14
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

58
RefSeq

4
UniProt

4
CCDS

CCDS48271.1, CCDS48272.1

Ensembl

ENSMUSG00000079550 (Evidence)
NCBI Gene

227157

			Length	Strain/Species	Flank
genomic	227157	NCBI Gene Model \| MGI Sequence Detail	42455	C57BL/6J	± kb
transcript	NM_001164682	RefSeq \| MGI Sequence Detail	2982	C57BL/6
polypeptide	Q6P7F1	UniProt \| EBI \| MGI Sequence Detail	635	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010545 MAGUK p55 subfamily member 4

(term hierarchy)
InterPro Domains

IPR020590 Guanylate kinase, conserved site

IPR008144 Guanylate kinase-like domain

IPR008145 Guanylate kinase/L-type calcium channel beta subunit

IPR004172 L27 domain

IPR014775 L27 domain, C-terminal

IPR036892 L27 domain superfamily

IPR050716 Membrane-associated guanylate kinase, MPP/CASK

IPR035600 MPP4, SH3 domain

IPR001478 PDZ domain

IPR036034 PDZ superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 17

cDNA 15

Primer pair 2

Antibodies 1

Microarray probesets 2

Summaries

All 41

Developmental Gene Expression 5

Gene Ontology 8

Phenotypes 10
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:244151 Kurkewich JL, et al., The miR-23a~27a~24-2 microRNA cluster buffers transcription and signaling pathways during hematopoiesis. PLoS Genet. 2017 Jul;13(7):e1006887

TSS for Mpp4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11819	Chr1:59200753-59200787 (-)	1,778 bp
Tssr11818	Chr1:59200718-59200752 (-)	1,813 bp
Tssr11817	Chr1:59190838-59190845 (-)	11,706 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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