Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Spam1tm1Tba
Name:	sperm adhesion molecule 1; targeted mutation 1, Tadashi Baba
MGI ID:	MGI:2386404
Synonyms:	Ph20-
Gene:	Spam1  Location: Chr6:24791187-24801047 bp, + strand  Genetic Position: Chr6, 11.28 cM, cytoband A2
Alliance:	Spam1tm1Tba page

Germline Transmission:	Earliest citation of germline transmission: J:78559
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of exon 2, which encodes the hyaluronidase domain, was replaced with a neomycin resistance cassette via homologous recombination. Testicular RNA from homozygous mutant animals did not contain gene transcripts as assayed by Northern blot. Western blot of cauda epididymal sperm protein extracts from homozygous mutants showed no immunoreactivity. (J:78559)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Spam1 Mutation:	32 strains or lines available

Original:	J:78559 Baba D, et al., Mouse sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg. J Biol Chem. 2002 Aug 16;277(33):30310-4
All:	7 reference(s)