Phenotypes associated with this allele
Allelic Composition |
Spam1tm1Tba/Spam1tm1Tba
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Genetic Background |
either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129S2/SvPas * ICR) |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spam1tm1Tba mutation
(1 available);
any
Spam1 mutation
(32 available)
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reproductive system
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• 30% reduction in ability of sperm to fertilize cumulus-intact eggs compared to wild-type
• ability of sperm to fertilize cumulus-free eggs is comparable to wild-type
• hyaluronidase activity of sperm protein extracts reduced by 80% compared to wild-type
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spam1tm1Tba mutation
(1 available);
any
Spam1 mutation
(32 available)
|
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reproductive system
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• sperm exhibit reduced accessibility to the Zona Pellucida surface
• increased accumulation on the oocyte-cumulus complex surface
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• sperm exhibit reduced accessibility to the Zona Pellucida surface
• increased accumulation on the oocyte-cumulus complex surface.
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