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Nup153 Gene Detail
Summary
  • Symbol
    Nup153
  • Name
    nucleoporin 153
  • Synonyms
    B130015D15Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385621
    NCBI Gene: 218210
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:46833381-46881416 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 24.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    147 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385621
 protein coding gene Chr13:46833369-46890682 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020515
 protein coding gene Chr13:45454846-45503648 (-)
A/J MGP_AJ_G0020469
 protein coding gene Chr13:43880821-43929067 (-)
AKR/J MGP_AKRJ_G0020446
 protein coding gene Chr13:45085451-45136508 (-)
BALB/cJ MGP_BALBcJ_G0020465
 protein coding gene Chr13:44087961-44136452 (-)
C3H/HeJ MGP_C3HHeJ_G0020264
 protein coding gene Chr13:44953837-45002189 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020898
 protein coding gene Chr13:46840606-46890720 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018483
 protein coding gene Chr13:41916501-41968725 (-)
CAST/EiJ MGP_CASTEiJ_G0019779
 protein coding gene Chr13:44881578-44932291 (-)
CBA/J MGP_CBAJ_G0020225
 protein coding gene Chr13:48790339-48842527 (-)
DBA/2J MGP_DBA2J_G0020347
 protein coding gene Chr13:43438172-43486318 (-)
FVB/NJ MGP_FVBNJ_G0020326
 protein coding gene Chr13:42954641-43002901 (-)
LP/J MGP_LPJ_G0020422
 protein coding gene Chr13:45688654-45737285 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020355
 protein coding gene Chr13:48611820-48662390 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020941
 protein coding gene Chr13:44766423-44815877 (-)
PWK/PhJ MGP_PWKPhJ_G0019535
 protein coding gene Chr13:43563556-43612374 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019363
 protein coding gene Chr13:43437239-43484553 (-)
WSB/EiJ MGP_WSBEiJ_G0019841
 protein coding gene Chr13:45098059-45146582 (-)



Homology
more
  • Human Ortholog
    NUP153, nucleoporin 153
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NUP153, nucleoporin 153
  • Synonyms
    HNUP153, N153
  • Links
    NCBI Gene ID: 9972
    neXtProt AC: NX_P49790
    UniProt: P49790

  • Chr Location
    6p22.3; chr6:17615035-17706925 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    36
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    7
  • cDNA Data
    17
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021374 Ensembl Gene Model | MGI Sequence Detail 48036 C57BL/6J ±  kb
    transcript ENSMUST00000021803 Ensembl | MGI Sequence Detail 6109 Not Applicable  
    polypeptide ENSMUSP00000021803 Ensembl | MGI Sequence Detail 1462 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • InterPro Domains
      IPR026054 Nuclear pore complex protein
      IPR013913 Nucleoporin Nup153, N-terminal
      IPR018892 Retro-transposon transporting motif
      IPR001876 Zinc finger, RanBP2-type
      IPR036443 Zinc finger, RanBP2-type superfamily
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2145538, MGI:2443046
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:292071 Kadota S, et al., Nucleoporin 153 links nuclear pore complex to chromatin architecture by mediating CTCF and cohesin binding. Nat Commun. 2020 May 25;11(1):2606
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory