Pnpla7 MGI Mouse Gene Detail - MGI:2385325 - patatin-like phospholipase domain containing 7

Symbol

Pnpla7
Name

patatin-like phospholipase domain containing 7
Synonyms

E430013P11Rik, MGC:6929, NRE

Feature Type

protein coding gene
IDs

MGI:2385325
NCBI Gene: 241274
Alliance

genome feature page
Transcription Start Sites

15 TSS

Sequence Map

Chr2:24866045-24944069 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 16.88 cM
Mapping Data

1 experiment

SNPs within 2kb

2287 from dbSNP Build 142
Strain Annotations

39

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385325	protein coding gene	Chr2:24865235-24944084 (+)
129S1/SvImJ	ENSMUSGG00200054851	protein coding gene	Chr2:21870304-21884892 (+)
129S1/SvImJ	ENSMUSGG00200054392	protein coding gene	Chr2:21853978-21869457 (+)
129S1/SvImJ	ENSMUSG00200051581	protein coding gene	Chr2:21925805-21927209 (+)
A/J	ENSMUSGG00195054905	protein coding gene	Chr2:21944868-21951873 (+)
A/J	ENSMUSG00195042938	protein coding gene	Chr2:22016272-22017676 (+)
A/J	ENSMUSGG00195054902	protein coding gene	Chr2:21960780-21975356 (+)
AKR/J	ENSMUSG00220053046	protein coding gene	Chr2:22134112-22135516 (+)
AKR/J	ENSMUSGG00220054306	protein coding gene	Chr2:22062722-22077813 (+)
AKR/J	ENSMUSGG00220054303	protein coding gene	Chr2:22078636-22093209 (+)
BALB/cJ	ENSMUSGG00180055002	protein coding gene	Chr2:21971933-21986521 (+)
BALB/cJ	ENSMUSG00180051745	protein coding gene	Chr2:22027445-22028849 (+)
BALB/cJ	ENSMUSGG00180055004	protein coding gene	Chr2:21955606-21971086 (+)
C3H/HeJ	ENSMUSGG00175055160	protein coding gene	Chr2:21936137-21950725 (+)
C3H/HeJ	ENSMUSGG00175055158	protein coding gene	Chr2:21919811-21927178 (+)
C3H/HeJ	ENSMUSG00175047103	protein coding gene	Chr2:21991636-21993040 (+)
C57BL/6NJ	ENSMUSG00215047147	protein coding gene	Chr2:22050324-22051729 (+)
C57BL/6NJ	ENSMUSGG00215055208	protein coding gene	Chr2:21978480-21993960 (+)
C57BL/6NJ	ENSMUSGG00215055207	protein coding gene	Chr2:21994807-22009397 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023245	protein coding gene	Chr2:20869512-20951759 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210016042	protein coding gene	Chr2:22030608-22032012 (+)
CBA/J	ENSMUSGG00210055110	protein coding gene	Chr2:21975110-21989698 (+)
CBA/J	ENSMUSGG00210055109	protein coding gene	Chr2:21958786-21966153 (+)
DBA/2J	ENSMUSGG00185057897	protein coding gene	Chr2:21859155-21874243 (+)
DBA/2J	ENSMUSGG00185057333	protein coding gene	Chr2:21875066-21889636 (+)
DBA/2J	ENSMUSG00185052485	protein coding gene	Chr2:21930549-21931953 (+)
FVB/NJ	ENSMUSG00205044312	protein coding gene	Chr2:21784639-21786043 (+)
FVB/NJ	ENSMUSGG00205054632	protein coding gene	Chr2:21712396-21728045 (+)
FVB/NJ	ENSMUSGG00205054633	protein coding gene	Chr2:21728870-21743467 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSGG00230055784	protein coding gene	Chr2:23789997-23805475 (+)
LP/J	ENSMUSG00230037634	protein coding gene	Chr2:23861809-23863213 (+)
LP/J	ENSMUSGG00230055746	protein coding gene	Chr2:23806322-23820908 (+)
NOD/ShiLtJ	ENSMUSGG00190055094	protein coding gene	Chr2:21966611-21981199 (+)
NOD/ShiLtJ	ENSMUSGG00190055093	protein coding gene	Chr2:21950287-21965764 (+)
NOD/ShiLtJ	ENSMUSG00190030338	protein coding gene	Chr2:22022114-22023518 (+)
NZO/HlLtJ	ENSMUSG00225010185	protein coding gene	Chr2:31612473-31613877 (+)
NZO/HlLtJ	ENSMUSGG00225055728	protein coding gene	Chr2:31556982-31571568 (+)
NZO/HlLtJ	ENSMUSGG00225055727	protein coding gene	Chr2:31540658-31548025 (+)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010030365	protein coding gene	Chr2:22552361-22630993 (+)
WSB/EiJ	no annotation

Human Ortholog

PNPLA7, patatin like domain 7, lysophospholipase

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PNPLA7, patatin like domain 7, lysophospholipase
Synonyms

C9orf111, NTEL1, NTE-R1
Links

HGNC:24768

NCBI Gene ID: 375775

UniProt: Q6ZV29
Chr Location

9q34.3; chr9:137459952-137550431 (-) GRCh38

MGI Vertebrate Homology

Pnpla7 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PNPLA7
Gene Tree

Pnpla7

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Phenotype Summary

25 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

3
Gene trapped

3
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

66 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit premature death, weight loss, kyphosis, thin muscle fibers, decreased subcutaneous and visceral adipose tissue, increased food intake, hyperactivity, increased oxygen consumption, decreased body temperature, and browned white adipose tissue morphology with altered choline metabolism.

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All GO Annotations

19
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

612
Tissues

9
cDNA Data

76
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pnpla6

ZFIN pnpla7b

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All Sequences

144
RefSeq

48
UniProt

7
CCDS

CCDS50522.1

Ensembl

ENSMUSG00000036833 (Evidence)
NCBI Gene

241274

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036833	Ensembl Gene Model \| MGI Sequence Detail	78025	C57BL/6J	± kb
transcript	ENSMUST00000045295	Ensembl \| MGI Sequence Detail	4574	Not Applicable
polypeptide	ENSMUSP00000044078	Ensembl \| MGI Sequence Detail	1352	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000012947 patatin-like phospholipase domain-containing protein 7

(term hierarchy)
EC

3.1.1.-, 3.1.1.5
InterPro Domains

IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase

IPR000595 Cyclic nucleotide-binding domain

IPR018490 Cyclic nucleotide-binding domain superfamily

IPR056556 Lysophospholipase NTE1-like, P-loop domain

IPR050301 Neuropathy target esterase

IPR002641 Patatin-like phospholipase domain

IPR014710 PpnP-like, jelly roll fold
GlyGen

A2AJ88 1 site, 1 N-linked glycan (1 site)

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All nucleic 77

cDNA 77

Microarray probesets 4

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MGI:2442947

Summaries

All 41

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 8
Earliest

J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
Latest

J:373617 Ji X, et al., PNPLA7 mediates Parkin-mitochondrial recruitment in adipose tissue for mitophagy and inhibits browning. Nat Commun. 2025 Jul 19;16(1):6651

TSS for Pnpla7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16635	Chr2:24865203-24865231 (+)	-828 bp
Tssr16636	Chr2:24865235-24865248 (+)	-803 bp
Tssr16637	Chr2:24865320-24865332 (+)	-719 bp
Tssr16638	Chr2:24865348-24865358 (+)	-692 bp
Tssr16639	Chr2:24866039-24866055 (+)	2 bp
Tssr16640	Chr2:24866058-24866122 (+)	45 bp
Tssr16641	Chr2:24866129-24866152 (+)	96 bp
Tssr16642	Chr2:24866192-24866204 (+)	153 bp
Tssr16643	Chr2:24867933-24867943 (+)	1,893 bp
Tssr16644	Chr2:24873688-24873697 (+)	7,648 bp
Tssr16645	Chr2:24882644-24882663 (+)	16,609 bp
Tssr16646	Chr2:24884397-24884406 (+)	18,357 bp
Tssr16647	Chr2:24915622-24915627 (+)	49,580 bp
Tssr428	Chr2:24937983-24937994 (+)	71,944 bp
Tssr16648	Chr2:24941654-24941696 (+)	75,630 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24