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Dkk4 Gene Detail
Summary
  • Symbol
    Dkk4
  • Name
    dickkopf WNT signaling pathway inhibitor 4
  • Synonyms
    MGC:25705
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385299
    NCBI Gene: 234130
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:23114059-23117563 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.42 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385299
 protein coding gene Chr8:23113701-23117563 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033455
 protein coding gene Chr8:20479875-20483560 (+)
A/J MGP_AJ_G0033435
 protein coding gene Chr8:19815703-19819219 (+)
AKR/J MGP_AKRJ_G0033360
 protein coding gene Chr8:20464190-20469123 (+)
BALB/cJ MGP_BALBcJ_G0033431
 protein coding gene Chr8:19939320-19942805 (+)
C3H/HeJ MGP_C3HHeJ_G0033145
 protein coding gene Chr8:20664763-20670400 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033947
 protein coding gene Chr8:21348550-21353392 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030900
 protein coding gene Chr8:17144049-17147500 (+)
CAST/EiJ MGP_CASTEiJ_G0032471
 protein coding gene Chr8:20081051-20084512 (+)
CBA/J MGP_CBAJ_G0033120
 protein coding gene Chr8:22201459-22206048 (+)
DBA/2J MGP_DBA2J_G0033275
 protein coding gene Chr8:19781175-19784623 (+)
FVB/NJ MGP_FVBNJ_G0033219
 protein coding gene Chr8:19580880-19585215 (+)
LP/J MGP_LPJ_G0033364
 protein coding gene Chr8:20477712-20481189 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033262
 protein coding gene Chr8:21798453-21801968 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033966
 protein coding gene Chr8:20371888-20376326 (+)
PWK/PhJ MGP_PWKPhJ_G0032183
 protein coding gene Chr8:19368449-19371980 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032016
 protein coding gene Chr8:19751599-19755117 (+)
WSB/EiJ MGP_WSBEiJ_G0032587
 protein coding gene Chr8:20574141-20578421 (+)



Homology
more
  • Human Ortholog
    DKK4, dickkopf WNT signaling pathway inhibitor 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DKK4, dickkopf WNT signaling pathway inhibitor 4
  • Synonyms
    DKK-4
  • Links
    NCBI Gene ID: 27121
    neXtProt AC: NX_Q9UBT3
    UniProt: Q9UBT3

  • Chr Location
    8p11.21; chr8:42374063-42391322 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional ready allele are phenotypically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    163
  • cDNA Data
    9
  • Literature Summary
    40
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031535 Ensembl Gene Model | MGI Sequence Detail 3505 C57BL/6J ±  kb
    transcript ENSMUST00000033936 Ensembl | MGI Sequence Detail 1315 Not Applicable  
    polypeptide ENSMUSP00000033936 Ensembl | MGI Sequence Detail 221 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000006502 dickkopf-related protein 4
      (term hierarchy)
    • InterPro Domains
      IPR006796 Dickkopf, N-terminal cysteine-rich
      IPR048500 Dickkopf-related protein 1/2/4, C-terminal subdomain 1
      IPR048499 Dickkopf-related protein 1/2/4, C-terminal subdomain 2
      IPR039863 Dickkopf related protein 1-4
      IPR047299 Dickkopf-related protein 4, second cysteine-rich domain
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 9
      Primer pair 6
      Other 5

      Microarray probesets 2
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 40
      Gene Ontology 2
      Phenotypes 10
    • Earliest
      J:94639 Diep DB, et al., Characterisation of the Wnt antagonists and their response to conditionally activated Wnt signalling in the developing mouse forebrain. Brain Res Dev Brain Res. 2004 Nov 25;153(2):261-70
    • Latest
      J:341969 Jacob T, et al., Molecular and spatial landmarks of early mouse skin development. Dev Cell. 2023 Oct 23;58(20):2140-2162.e5
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory