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Pgap2 Gene Detail
Summary
  • Symbol
    Pgap2
  • Name
    post-GPI attachment to proteins 2
  • Synonyms
    1810006G21Rik, clpex, Frag1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385286
    NCBI Gene: 233575
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:101859415-101887774 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, Syntenic
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    348 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385286
 protein coding gene Chr7:101859153-101887774 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032605
 protein coding gene Chr7:105245679-105281536 (+)
A/J MGP_AJ_G0032581
 protein coding gene Chr7:102564730-102593983 (+)
AKR/J MGP_AKRJ_G0032517
 protein coding gene Chr7:105012729-105043293 (+)
BALB/cJ MGP_BALBcJ_G0032592
 protein coding gene Chr7:102267384-102296883 (+)
C3H/HeJ MGP_C3HHeJ_G0032306
 protein coding gene Chr7:105412334-105444862 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033089
 protein coding gene Chr7:109207510-109238785 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030083
 protein coding gene Chr7:104917209-104946084 (+)
CAST/EiJ MGP_CASTEiJ_G0031632
 protein coding gene Chr7:96957967-96989562 (+)
CBA/J MGP_CBAJ_G0032272
 protein coding gene Chr7:113021911-113062228 (+)
DBA/2J MGP_DBA2J_G0032424
 protein coding gene Chr7:100887922-100917107 (+)
FVB/NJ MGP_FVBNJ_G0032380
 protein coding gene Chr7:100672799-100704126 (+)
LP/J MGP_LPJ_G0032513
 protein coding gene Chr7:106556444-106589691 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032414
 protein coding gene Chr7:114306845-114338727 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033111
 protein coding gene Chr7:104290729-104319841 (+)
PWK/PhJ MGP_PWKPhJ_G0031350
 protein coding gene Chr7:94007848-94038005 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031194
 protein coding gene Chr7:91585419-91619131 (+)
WSB/EiJ MGP_WSBEiJ_G0031749
 protein coding gene Chr7:104977146-105010346 (+)



Homology
more
  • Human Ortholog
    PGAP2, post-GPI attachment to proteins 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGAP2, post-GPI attachment to proteins 2
  • Synonyms
    CWH43-N, FRAG1, HPMRS3, MRT17, MRT21
  • Links
    NCBI Gene ID: 27315
    neXtProt AC: NX_Q9UHJ9
    UniProt: Q9UHJ9

  • Chr Location
    11p15.4; chr11:3797724-3826371 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PGAP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mouse embryos homozygous for an ENU-induced mutation exhibit a flattened head, edema, exencephaly, cleft lip and palate, short humeri and radii, and bone ossification deficiencies . Homozygous KO is early embryonic lethal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    44
  • cDNA Data
    88
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030990 Ensembl Gene Model | MGI Sequence Detail 28360 C57BL/6J ±  kb
    transcript ENSMUST00000033292 Ensembl | MGI Sequence Detail 1201 Not Applicable  
    polypeptide ENSMUSP00000033292 Ensembl | MGI Sequence Detail 254 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 88

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1925618, MGI:2142307, MGI:5056358
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 22
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:277316 Lukacs M, et al., Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival. Elife. 2019 Jun 24;8:e45248
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory