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Chtf18 Gene Detail
Summary
  • Symbol
    Chtf18
  • Name
    CTF18, chromosome transmission fidelity factor 18
  • Synonyms
    6030457M03Rik, CTF18
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384887
    NCBI Gene: 214901
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25938004-25946409 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    36 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384887
 protein coding gene Chr17:25937900-25946409 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023361
 protein coding gene Chr17:24810133-24818618 (-)
A/J MGP_AJ_G0023320
 protein coding gene Chr17:24089482-24097973 (-)
AKR/J MGP_AKRJ_G0023286
 protein coding gene Chr17:24195033-24203493 (-)
BALB/cJ MGP_BALBcJ_G0023325
 protein coding gene Chr17:24314164-24323838 (-)
C3H/HeJ MGP_C3HHeJ_G0023085
 protein coding gene Chr17:24577391-24585859 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023767
 protein coding gene Chr17:25860624-25869088 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021243
 protein coding gene Chr17:21551679-21560167 (-)
CAST/EiJ MGP_CASTEiJ_G0022587
 protein coding gene Chr17:24456004-24465712 (-)
CBA/J MGP_CBAJ_G0023060
 protein coding gene Chr17:26768014-26779278 (-)
DBA/2J MGP_DBA2J_G0023190
 protein coding gene Chr17:23691095-23699647 (-)
FVB/NJ MGP_FVBNJ_G0023160
 protein coding gene Chr17:23427981-23437502 (-)
LP/J MGP_LPJ_G0023267
 protein coding gene Chr17:25105164-25113602 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023179
 protein coding gene Chr17:26384710-26393163 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023807
 protein coding gene Chr17:24503579-24523360 (-)
PWK/PhJ MGP_PWKPhJ_G0022336
 protein coding gene Chr17:22452971-22461446 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022154
 protein coding gene Chr17:22579939-22590516 (-)
WSB/EiJ MGP_WSBEiJ_G0022650
 protein coding gene Chr17:24564880-24573327 (-)



Homology
more
  • Human Ortholog
    CHTF18, chromosome transmission fidelity factor 18
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHTF18, chromosome transmission fidelity factor 18
  • Synonyms
    C16orf41, C321D2.2, C321D2.3, C321D2.4, CHL12, Ctf18, RUVBL
  • Links
    NCBI Gene ID: 63922
    neXtProt AC: NX_Q8WVB6
    UniProt: Q8WVB6

  • Chr Location
    16p13.3; chr16:788046-800737 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 3 alleles in 3 genetic backgrounds
    4 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial prenatal lethality, reduced body and testis weight, defective male meiosis, impaired spermatogenesis, oligozoospermia, and reduced male fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    787
  • Tissues
    51
  • cDNA Data
    6
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 214901 NCBI Gene Model | MGI Sequence Detail 8406 C57BL/6J ±  kb
    transcript NM_145409 RefSeq | MGI Sequence Detail 3163 C57BL/6  
    polypeptide Q8BIW9 UniProt | EBI | MGI Sequence Detail 969 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 6
      Primer pair 5

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2441708
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 12
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:314103 Ulmke PA, et al., Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex. Stem Cell Reports. 2021 Apr 13;16(4):968-984
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    04/16/2024
    MGI 6.23     		The Jackson Laboratory