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Usp11 Gene Detail
Summary
  • Symbol
    Usp11
  • Name
    ubiquitin specific peptidase 11
  • Synonyms
    6230415D12Rik, MGC:6649
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384312
    NCBI Gene: 236733
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:20570148-20586778 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 16.20 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    384 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384312
 protein coding gene ChrX:20570145-20586778 (+)
129S1/SvImJ ENSMUSG00200014857
 protein coding gene ChrX:15333528-15350163 (+)
A/J ENSMUSG00195007400
 protein coding gene ChrX:15334674-15351309 (+)
AKR/J ENSMUSG00220017562
 protein coding gene ChrX:14829772-14846407 (+)
BALB/cJ ENSMUSG00180021683
 protein coding gene ChrX:15268460-15285095 (+)
C3H/HeJ ENSMUSG00175028678
 protein coding gene ChrX:15308980-15325613 (+)
C57BL/6NJ ENSMUSG00215013643
 protein coding gene ChrX:15913131-15929764 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032966
 protein coding gene ChrX:13931896-13948485 (+)
CAST/EiJ ENSTCUG00005025946
 protein coding gene ChrX:15251139-15267564 (+)
CBA/J ENSMUSG00210020288
 protein coding gene ChrX:15365639-15382274 (+)
DBA/2J ENSMUSG00185031277
 protein coding gene ChrX:21966233-21982868 (+)
FVB/NJ ENSMUSG00205019268
 protein coding gene ChrX:14909791-14926426 (+)
JF1/MsJ ENSUMUG00000019889
 protein coding gene ChrX:35795932-35812392 (+)
LP/J ENSMUSG00230006010
 protein coding gene ChrX:26535625-26552260 (+)
NOD/ShiLtJ ENSMUSG00190027144
 protein coding gene ChrX:15303198-15319833 (+)
NZO/HlLtJ ENSMUSG00225041101
 protein coding gene ChrX:31775477-31792110 (+)
PWK/PhJ ENSLUMG00010015501
 protein coding gene ChrX:15201952-15218408 (+)
SPRET/EiJ ENSMSPG00010010350
 protein coding gene ChrX:16471168-16487614 (+)
WSB/EiJ ENSIUOG00005032090
 protein coding gene ChrX:11915420-11932040 (+)



Homology
more
  • Human Ortholog
    USP11, ubiquitin specific peptidase 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP11, ubiquitin specific peptidase 11
  • Synonyms
    UHX1
  • Links
    NCBI Gene ID: 8237
    UniProt: P51784

  • Chr Location
    Xp11.3; chrX:47232866-47248328 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for a null allele display enlarged prostate glands and hyperplastic prostate gland epithelium. Female homozygous null mice are viable.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    635
  • Tissues
    4
  • cDNA Data
    74
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 236733 NCBI Gene Model | MGI Sequence Detail 16631 C57BL/6J ±  kb
    transcript NM_001358931 RefSeq | MGI Sequence Detail 3535 C57BL/6  
    polypeptide Q99K46 UniProt | EBI | MGI Sequence Detail 921 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000017147 ubiquitin carboxyl-terminal hydrolase 11
      (term hierarchy)
    • EC
      3.4.19.12
    • InterPro Domains
      IPR035927 DUSP-like superfamily
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR006615 Peptidase C19, ubiquitin-specific peptidase, DUSP domain
      IPR050185 Ubiquitin carboxyl-terminal hydrolase
      IPR028135 Ubiquitin-like domain, USP-type
      IPR018200 Ubiquitin specific protease, conserved site
      IPR028889 Ubiquitin specific protease USP, catalytic domain
    • GlyGen
      Q99K46 4 sites, 1 O-linked glycan (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 75

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2444517
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:357577 Qian T, et al., USP11 deubiquitinates E-cadherin and maintains the luminal fate of mammary tumor cells to suppress breast cancer. J Biol Chem. 2024 Sep 11;300(10):107768
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory