Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hspa1atm1Msk
Name:	heat shock protein 1A; targeted mutation 1, Demetrius Moskophidis
MGI ID:	MGI:2183895
Synonyms:	hsp70.3-
Gene:	Hspa1a  Location: Chr17:35188335-35191132 bp, - strand  Genetic Position: Chr17, 18.51 cM
Alliance:	Hspa1atm1Msk page

Germline Transmission:	Earliest citation of germline transmission: J:72943
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Most of the coding region of the gene (codons 1-633) was replaced with an in frame lacZ floxed TK-neo cassette via homologous recombination. Southern blot and PCR genotype analysis confirmed the targeted allele in homozygous mutant animals. (J:72943)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hspa1a Mutation:	23 strains or lines available

Original:	J:72943 Huang L, et al., Insights into Regulation and Function of the Major Stress-Induced hsp70 Molecular Chaperone In Vivo: Analysis of Mice with Targeted Gene Disruption of the hsp70.1 or hsp70.3 Gene. Mol Cell Biol. 2001 Dec;21(24):8575-91
All:	1 reference(s)