Phenotypes associated with this allele

• Allele Symbol: Hspa1a^tm1Msk
• Allele Name: targeted mutation 1, Demetrius Moskophidis
• Allele ID: MGI:2183895
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hspa1a^tm1Msk/Hspa1a^tm1Msk	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3719790
ht2	Hspa1a^tm1Msk/Hspa1a^+	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3719791

Genotype
MGI:3719790

hm1

• Allelic Composition: Hspa1a^tm1Msk/Hspa1a^tm1Msk
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:72943 )

• in an in vitro assay, macrophages are more sensitive to thermal stress

• thermotolerance of mouse embryonic fibroblast cells is less than in wild-type mice but greater than that in Hspa1b^tm1Msk homozygotes

increased sensitivity to induced cell death ( J:72943 )

• in an in vitro assay, mouse embryonic fibroblasts exhibit greater levels of thermal stress-induced apoptosis

Genotype
MGI:3719791

ht2

• Allelic Composition: Hspa1a^tm1Msk/Hspa1a⁺
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

cellular

abnormal cell physiology ( J:72943 )

• in an in vitro assay, macrophages are more sensitive to thermal stress than wild-type macrophages but not as sensitive as Hspa1a^tm1Msk homozygotes