About   Help   FAQ
Agap3 Gene Detail
Summary
  • Symbol
    Agap3
  • Name
    ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
  • Synonyms
    Centg3, Crag, MGC:37541, MRIP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2183446
    NCBI Gene: 213990
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:24657175-24707045 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 11.81 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1084 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2183446
 protein coding gene Chr5:24657175-24707045 (+)
129S1/SvImJ ENSMUSG00200013212
 protein coding gene Chr5:20264139-20313902 (+)
A/J ENSMUSG00195037035
 protein coding gene Chr5:19735140-19785015 (+)
AKR/J ENSMUSG00220035134
 protein coding gene Chr5:19817785-19867657 (+)
BALB/cJ ENSMUSG00180021213
 protein coding gene Chr5:19602120-19651999 (+)
C3H/HeJ ENSMUSG00175045937
 protein coding gene Chr5:21533372-21583247 (+)
C57BL/6NJ ENSMUSG00215039929
 protein coding gene Chr5:20169060-20218936 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027014
 protein coding gene Chr5:19367457-19417413 (+)
CAST/EiJ ENSTCUG00005003312
 protein coding gene Chr5:19738039-19787983 (+)
CBA/J ENSMUSG00210044109
 protein coding gene Chr5:20572654-20622532 (+)
DBA/2J ENSMUSG00185037280
 protein coding gene Chr5:22104690-22154465 (+)
FVB/NJ ENSMUSG00205018412
 protein coding gene Chr5:19325150-19375022 (+)
JF1/MsJ ENSUMUG00000003015
 protein coding gene Chr5:26667587-26717363 (+)
LP/J ENSMUSG00230025563
 protein coding gene Chr5:26546128-26595906 (+)
NOD/ShiLtJ ENSMUSG00190004249
 protein coding gene Chr5:19639079-19688836 (+)
NZO/HlLtJ ENSMUSG00225016953
 protein coding gene Chr5:31955205-32005088 (+)
PWK/PhJ ENSLUMG00010031436
 protein coding gene Chr5:19706157-19756000 (+)
SPRET/EiJ ENSMSPG00010031778
 protein coding gene Chr5:20572070-20621874 (+)
WSB/EiJ ENSIUOG00005041917
 protein coding gene Chr5:22461543-22511421 (+)



Homology
more
  • Human Ortholog
    AGAP3, ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGAP3, ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
  • Synonyms
    AGAP-3, CENTG3, cnt-g3, CRAG, MRIP-1
  • Links
    NCBI Gene ID: 116988
    UniProt: Q96P47

  • Chr Location
    7q36.1; chr7:151085831-151144436 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit postnatal lethality and hyperactivity. Mice homozygous for a conditional allele activated in the dorsal forebrain exhibit immature dentate gyrus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    600
  • Tissues
    3
  • cDNA Data
    74
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 213990 NCBI Gene Model | MGI Sequence Detail 49871 C57BL/6J ±  kb
    transcript NM_139153 RefSeq | MGI Sequence Detail 3207 C57BL/6  
    polypeptide Q8VHH5 UniProt | EBI | MGI Sequence Detail 910 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 76
      cDNA 74
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141107
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 5
      Phenotypes 18
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:333903 Viard J, et al., Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease. Life Sci Alliance. 2022 Dec;5(12):e202101205
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory