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Adgrf2 Gene Detail
Summary
  • Symbol
    Adgrf2
  • Name
    adhesion G protein-coupled receptor F2
  • Synonyms
    Gpr111, PGR20
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182728
    NCBI Gene: 435529
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:43007021-43053070 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.66 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1739 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182728
 protein coding gene Chr17:43004919-43054646 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023769
 protein coding gene Chr17:43560734-43593375 (-)
A/J MGP_AJ_G0023727
 protein coding gene Chr17:42582378-42619018 (-)
AKR/J MGP_AKRJ_G0023698
 protein coding gene Chr17:42772022-42811915 (-)
BALB/cJ MGP_BALBcJ_G0023731
 protein coding gene Chr17:42488367-42522064 (-)
C3H/HeJ MGP_C3HHeJ_G0023495
 protein coding gene Chr17:43471754-43507491 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024173
 protein coding gene Chr17:45462000-45502942 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021624
 protein coding gene Chr17:39473729-39515260 (-)
CAST/EiJ MGP_CASTEiJ_G0022976
 protein coding gene Chr17:43474585-43528904 (-)
CBA/J MGP_CBAJ_G0023471
 protein coding gene Chr17:47116977-47156412 (-)
DBA/2J MGP_DBA2J_G0023597
 protein coding gene Chr17:41396467-41430514 (-)
FVB/NJ MGP_FVBNJ_G0023564
 protein coding gene Chr17:40946809-40992100 (-)
LP/J MGP_LPJ_G0023678
 protein coding gene Chr17:44202886-44251198 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023593
 protein coding gene Chr17:46743137-46797219 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024219
 protein coding gene Chr17:43090864-43138999 (-)
PWK/PhJ MGP_PWKPhJ_G0022721
 protein coding gene Chr17:40637591-40690040 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022536
 protein coding gene Chr17:40031833-40068476 (-)
WSB/EiJ MGP_WSBEiJ_G0023041
 protein coding gene Chr17:43623612-43680007 (-)



Homology
more
  • Human Ortholog
    ADGRF2P, adhesion G protein-coupled receptor F2, pseudogene
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADGRF2P, adhesion G protein-coupled receptor F2, pseudogene
  • Synonyms
    ADGRF2, GPR111, hGPCR35, PGR20
  • Links
    NCBI Gene ID: 222611
    UniProt: Q8IZF7

  • Chr Location
    6p12.3; chr6:47656472-47697794 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 3 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele exhibit normal viability and fertility. Mice homozygous for a different null allele exhibit dental enamel hypomineralization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    736
  • Tissues
    27
  • cDNA Data
    3
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000057899 Ensembl Gene Model | MGI Sequence Detail 46050 C57BL/6J ±  kb
transcript ENSMUST00000239223 Ensembl | MGI Sequence Detail 2544 Not Applicable  
polypeptide ENSMUSP00000159259 Ensembl | MGI Sequence Detail 673 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 4
    cDNA 3
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 22
    Developmental Gene Expression 1
    Gene Ontology 1
    Phenotypes 4
  • Earliest
    J:90622 Bjarnadottir TK, et al., The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics. 2004 Jul;84(1):23-33
  • Latest
    J:341655 Chiba Y, et al., Deficiency of G protein-coupled receptor Gpr111/Adgrf2 causes enamel hypomineralization in mice by alteration of the expression of kallikrein-related peptidase 4 (Klk4) during pH cycling process. FASEB J. 2023 Apr;37(4):e22861
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory