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Hook2 Gene Detail
Summary
  • Symbol
    Hook2
  • Name
    hook microtubule tethering protein 2
  • Synonyms
    A630054I03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2181664
    NCBI Gene: 170833
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85717232-85729978 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.44 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    355 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2181664
 protein coding gene Chr8:85715402-85729981 (+)
129S1/SvImJ ENSMUSG00200025064
 protein coding gene Chr8:80082168-80094788 (+)
A/J ENSMUSG00195014836
 protein coding gene Chr8:80440169-80452811 (+)
AKR/J ENSMUSG00220022324
 protein coding gene Chr8:80481776-80494396 (+)
BALB/cJ ENSMUSG00180019775
 protein coding gene Chr8:80280895-80293501 (+)
C3H/HeJ ENSMUSG00175010874
 protein coding gene Chr8:80375846-80388487 (+)
C57BL/6NJ ENSMUSG00215009757
 protein coding gene Chr8:80013550-80026304 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031322
 protein coding gene Chr8:76337155-76351842 (+)
CAST/EiJ ENSTCUG00005034705
 protein coding gene Chr8:79890741-79903318 (+)
CBA/J ENSMUSG00210019926
 protein coding gene Chr8:80362962-80375615 (+)
DBA/2J ENSMUSG00185037117
 protein coding gene Chr8:86471571-86484211 (+)
FVB/NJ ENSMUSG00205023264
 protein coding gene Chr8:79418801-79431458 (+)
JF1/MsJ ENSUMUG00000013924
 protein coding gene Chr8:88780234-88792986 (+)
LP/J ENSMUSG00230024221
 protein coding gene Chr8:90079160-90091777 (+)
NOD/ShiLtJ ENSMUSG00190015069
 protein coding gene Chr8:80439331-80451963 (+)
NZO/HlLtJ ENSMUSG00225039516
 protein coding gene Chr8:93474241-93486990 (+)
PWK/PhJ ENSLUMG00010028039
 protein coding gene Chr8:80117207-80129997 (+)
SPRET/EiJ ENSMSPG00010024938
 protein coding gene Chr8:82030834-82043384 (+)
WSB/EiJ ENSIUOG00005018231
 protein coding gene Chr8:81177095-81189721 (+)



Homology
more
  • Human Ortholog
    HOOK2, hook microtubule tethering protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOOK2, hook microtubule tethering protein 2
  • Synonyms
    HK2
  • Links
    NCBI Gene ID: 29911
    UniProt: Q96ED9

  • Chr Location
    19p13.13; chr19:12762640-12872740 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    22
  • cDNA Data
    68
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000052566 Ensembl Gene Model | MGI Sequence Detail 12747 C57BL/6J ±  kb
    transcript ENSMUST00000064495 Ensembl | MGI Sequence Detail 2580 Not Applicable  
    polypeptide ENSMUSP00000067752 Ensembl | MGI Sequence Detail 716 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 68

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2442857
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 41
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory