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Il31ra Gene Detail
Summary
  • Symbol
    Il31ra
  • Name
    interleukin 31 receptor A
  • Synonyms
    GLM-R, GPL
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180511
    NCBI Gene: 218624
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:112649439-112717266 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 63.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2091 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180511
 protein coding gene Chr13:112649439-112730894 (-)
129S1/SvImJ ENSMUSG00200030834
 protein coding gene Chr13:107118708-107193276 (-)
A/J ENSMUSG00195013235
 protein coding gene Chr13:107619451-107690999 (-)
AKR/J ENSMUSG00220027747
 protein coding gene Chr13:106065154-106139733 (-)
BALB/cJ ENSMUSG00180029154
 protein coding gene Chr13:108215188-108289769 (-)
C3H/HeJ ENSMUSG00175025605
 protein coding gene Chr13:108292793-108367381 (-)
C57BL/6NJ ENSMUSG00215015980
 protein coding gene Chr13:108316460-108391018 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018892
 protein coding gene Chr13:105792122-105835326 (-)
CAST/EiJ ENSTCUG00005025259
 protein coding gene Chr13:107338434-107410096 (-)
CBA/J ENSMUSG00210010583
 protein coding gene Chr13:107630459-107705032 (-)
DBA/2J ENSMUSG00185028171
 protein coding gene Chr13:111388997-111463577 (-)
FVB/NJ ENSMUSG00205006788
 protein coding gene Chr13:107065264-107136849 (-)
JF1/MsJ ENSUMUG00000010533
 protein coding gene Chr13:110847097-110918613 (-)
LP/J ENSMUSG00230010504
 protein coding gene Chr13:121587691-121662269 (-)
NOD/ShiLtJ ENSMUSG00190018267
 protein coding gene Chr13:107913560-107988146 (-)
NZO/HlLtJ ENSMUSG00225030506
 protein coding gene Chr13:113766947-113838523 (-)
PWK/PhJ ENSLUMG00010009237
 protein coding gene Chr13:106875563-106949193 (-)
SPRET/EiJ ENSMSPG00010015799
 protein coding gene Chr13:108553599-108630188 (-)
WSB/EiJ ENSIUOG00005008877
 protein coding gene Chr13:107085736-107159720 (-)



Homology
more
  • Human Ortholog
    IL31RA, interleukin 31 receptor A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL31RA, interleukin 31 receptor A
  • Synonyms
    CRL, CRL3, GLM-R, GLMR, GPL, hGLM-R, IL-31RA, PLCA2, PRO21384, zcytoR17
  • Links
    NCBI Gene ID: 133396
    UniProt: Q8NI17

  • Chr Location
    5q11.2; chr5:55839789-55922854 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human IL31RA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 5 alleles in 5 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display no apparent abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    613
  • Tissues
    10
  • cDNA Data
    34
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 218624 NCBI Gene Model | MGI Sequence Detail 67828 C57BL/6J ±  kb
    transcript NM_139299 RefSeq | MGI Sequence Detail 3680 C57BL/6  
    polypeptide Q8K5B1 UniProt | EBI | MGI Sequence Detail 716 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 34

      Microarray probesets 2
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:76557 Ghilardi N, et al., A Novel Type I Cytokine Receptor Is Expressed on Monocytes, Signals Proliferation, and Activates STAT-3 and STAT-5. J Biol Chem. 2002 May 10;277(19):16831-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory