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Neto1 Gene Detail
Summary
  • Symbol
    Neto1
  • Name
    neuropilin (NRP) and tolloid (TLL)-like 1
  • Synonyms
    C130005O10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180216
    NCBI Gene: 246317
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:86413077-86524843 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 58.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    861 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180216
protein coding gene Chr18:86411110-86524843 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024613
protein coding gene Chr18:87599648-87714812 (+)
A/J MGP_AJ_G0024580
protein coding gene Chr18:83772595-83881232 (+)
AKR/J MGP_AKRJ_G0024551
protein coding gene Chr18:86253077-86362756 (+)
BALB/cJ MGP_BALBcJ_G0024578
protein coding gene Chr18:83984998-84091783 (+)
C3H/HeJ MGP_C3HHeJ_G0024347
protein coding gene Chr18:86364998-86478554 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025025
protein coding gene Chr18:89819202-89933384 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022456
protein coding gene Chr18:82290524-82399608 (+)
CAST/EiJ MGP_CASTEiJ_G0023820
protein coding gene Chr18:86739764-86857316 (+)
CBA/J MGP_CBAJ_G0024317
protein coding gene Chr18:93058500-93173021 (+)
DBA/2J MGP_DBA2J_G0024446
protein coding gene Chr18:83294556-83401740 (+)
FVB/NJ MGP_FVBNJ_G0024413
protein coding gene Chr18:82651714-82763529 (+)
LP/J MGP_LPJ_G0024531
protein coding gene Chr18:87436580-87546026 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024443
protein coding gene Chr18:94408750-94534794 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025074
protein coding gene Chr18:86497950-86610795 (+)
PWK/PhJ MGP_PWKPhJ_G0023565
protein coding gene Chr18:83664151-83773138 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023371
protein coding gene Chr18:86479273-86594149 (+)
WSB/EiJ MGP_WSBEiJ_G0023882
protein coding gene Chr18:86413823-86522342 (+)



Homology
more
  • Human Ortholog
    NETO1, neuropilin and tolloid like 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NETO1, neuropilin and tolloid like 1
  • Synonyms
    BCTL1, BTCL1
  • Links
    NCBI Gene ID: 81832
    neXtProt AC: NX_Q8TDF5
    UniProt: Q8TDF5

  • Chr Location
    18q22.3; chr18:72742314-72868146 (-)  GRCh38

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    189 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit depressed long term potentiation, reduced NMDAR excitatory postsynaptic potentiation, and decreased spartial learning and working memory.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050321 Ensembl Gene Model | MGI Sequence Detail 111767 C57BL/6J ±  kb
transcript ENSMUST00000058829 Ensembl | MGI Sequence Detail 8352 Not Applicable  
polypeptide ENSMUSP00000057340 Ensembl | MGI Sequence Detail 533 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 5
Other
Accession IDs
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MGI:2147275, MGI:2443543
References
more
  • Summaries
    All 222
    Developmental Gene Expression 10
    Diseases 2
    Gene Ontology 9
    Phenotypes 189
  • Earliest
    J:76401 Stohr H, et al., A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain. Gene. 2002 Mar 20;286(2):223-31
  • Latest
    J:343733 Bernstein IR, et al., The hypoxia-inducible factor EPAS1 is required for spermatogonial stem cell function in regenerative conditions. iScience. 2023 Dec 15;26(12):108424

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory