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Lgi2 Gene Detail
Summary
  • Symbol
    Lgi2
  • Name
    leucine-rich repeat LGI family, member 2
  • Synonyms
    mKIAA1916
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180196
    NCBI Gene: 246316
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:52690859-52723689 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 28.25 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1061 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180196
 protein coding gene Chr5:52690859-52723804 (-)
129S1/SvImJ ENSMUSG00200001218
 protein coding gene Chr5:48243750-48276703 (-)
A/J ENSMUSG00195015089
 protein coding gene Chr5:47603302-47636291 (-)
AKR/J ENSMUSG00220000639
 protein coding gene Chr5:47672969-47705961 (-)
BALB/cJ ENSMUSG00180006309
 protein coding gene Chr5:47373256-47406208 (-)
C3H/HeJ ENSMUSG00175014492
 protein coding gene Chr5:49393167-49426159 (-)
C57BL/6NJ ENSMUSG00215001741
 protein coding gene Chr5:48165565-48198520 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027217
 protein coding gene Chr5:46490457-46523028 (-)
CAST/EiJ ENSTCUG00005003070
 protein coding gene Chr5:47524601-47557591 (-)
CBA/J ENSMUSG00210024063
 protein coding gene Chr5:48353560-48386551 (-)
DBA/2J ENSMUSG00185001149
 protein coding gene Chr5:50232032-50265021 (-)
FVB/NJ ENSMUSG00205002864
 protein coding gene Chr5:47182860-47215851 (-)
JF1/MsJ ENSUMUG00000000497
 protein coding gene Chr5:54805524-54842569 (-)
LP/J ENSMUSG00230010362
 protein coding gene Chr5:54907423-54940372 (-)
NOD/ShiLtJ ENSMUSG00190000466
 protein coding gene Chr5:47299079-47332068 (-)
NZO/HlLtJ ENSMUSG00225028400
 protein coding gene Chr5:60011708-60044697 (-)
PWK/PhJ ENSLUMG00010001490
 protein coding gene Chr5:47472596-47505572 (-)
SPRET/EiJ ENSMSPG00010012168
 protein coding gene Chr5:48964051-48992483 (-)
WSB/EiJ ENSIUOG00005018644
 protein coding gene Chr5:50272932-50305894 (-)



Homology
more
  • Human Ortholog
    LGI2, leucine rich repeat LGI family member 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LGI2, leucine rich repeat LGI family member 2
  • Synonyms
    LGIL2
  • Links
    NCBI Gene ID: 55203
    UniProt: Q8N0V4

  • Chr Location
    4p15.2; chr4:24992081-25030965 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    26 phenotype references
Mice homozygous develop normally with normal lifespans and fertility. Lgi2 and Lgi3 exhibit postnatal growth retardation, tremors, absent Kv1 channels, and postnatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    688
  • Tissues
    21
  • cDNA Data
    30
  • Literature Summary
    9
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 246316 NCBI Gene Model | MGI Sequence Detail 32831 C57BL/6J ±  kb
transcript NM_144945 RefSeq | MGI Sequence Detail 6315 C57BL/6  
polypeptide Q8K4Z0 UniProt | EBI | MGI Sequence Detail 550 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 30
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 62
    Developmental Gene Expression 9
    Gene Ontology 7
    Phenotypes 26
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:375944 Savonlehto T, et al., Lgi2-deficient mice manifest epileptiform activity in the developing hippocampal network and ADHD-like behavioural comorbidity in adulthood. Exp Neurol. 2025 Nov 1;396:115541
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory