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Rttn Gene Detail
Summary
  • Symbol
    Rttn
  • Name
    rotatin
  • Synonyms
    4921538A15Rik, C530033I08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179288
    NCBI Gene: 246102
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:88989914-89149140 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 58.93 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    446 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179288
 protein coding gene Chr18:88989860-89149140 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024616
 protein coding gene Chr18:90315312-90491891 (+)
A/J MGP_AJ_G0024583
 protein coding gene Chr18:86285314-86447092 (+)
AKR/J MGP_AKRJ_G0024554
 protein coding gene Chr18:88886752-89053070 (+)
BALB/cJ MGP_BALBcJ_G0024581
 protein coding gene Chr18:86560523-86723889 (+)
C3H/HeJ MGP_C3HHeJ_G0024350
 protein coding gene Chr18:89029148-89198645 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025029
 protein coding gene Chr18:92618930-92795463 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022459
 protein coding gene Chr18:85029646-85179643 (+)
CAST/EiJ MGP_CASTEiJ_G0023822
 protein coding gene Chr18:89498236-89683022 (+)
CBA/J MGP_CBAJ_G0024320
 protein coding gene Chr18:95914769-96094349 (+)
DBA/2J MGP_DBA2J_G0024449
 protein coding gene Chr18:85842003-86007073 (+)
FVB/NJ MGP_FVBNJ_G0024416
 protein coding gene Chr18:85164528-85322640 (+)
LP/J MGP_LPJ_G0024534
 protein coding gene Chr18:90187517-90350752 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024446
 protein coding gene Chr18:97744432-97952498 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025077
 protein coding gene Chr18:89174400-89344630 (+)
PWK/PhJ MGP_PWKPhJ_G0023568
 protein coding gene Chr18:86202411-86373177 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023375
 protein coding gene Chr18:89152118-89334304 (+)
WSB/EiJ MGP_WSBEiJ_G0023885
 protein coding gene Chr18:89079793-89259493 (+)



Homology
more
  • Human Ortholog
    RTTN, rotatin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RTTN, rotatin
  • Synonyms
    MSSP
  • Links
    NCBI Gene ID: 25914
    neXtProt AC: NX_Q86VV8
    UniProt: Q86VV8

  • Chr Location
    18q22.2; chr18:70003031-70205726 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an insertional mutation exhibit embryonic lethality and neurulation defects resulting in the arrest of gastrulation movements and abnormal left-right specification in the heart.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    30
  • cDNA Data
    31
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023066 Ensembl Gene Model | MGI Sequence Detail 159227 C57BL/6J ±  kb
    transcript ENSMUST00000023828 Ensembl | MGI Sequence Detail 7271 Not Applicable  
    polypeptide ENSMUSP00000023828 Ensembl | MGI Sequence Detail 2226 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 34
      cDNA 31
      Primer pair 1
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918209, MGI:2147258, MGI:2441910
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 11
    • Earliest
      J:45709 Melloy PG, et al., No turning, a mouse mutation causing left-right and axial patterning defects. Dev Biol. 1998 Jan 1;193(1):77-89
    • Latest
      J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory