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Defb10 Gene Detail
Summary
  • Symbol
    Defb10
  • Name
    defensin beta 10
  • Synonyms
    Defb7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179205
    NCBI Gene: 246085
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:22348917-22352027 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.49 cM, cytoband A4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179205
 protein coding gene Chr8:22348917-22352027 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033434
 protein coding gene Chr8:19635864-19643047 (+)
A/J MGP_AJ_G0033414
 protein coding gene Chr8:19043889-19047695 (+)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0033410
 protein coding gene Chr8:19172096-19175540 (+)
C3H/HeJ MGP_C3HHeJ_G0033124
 protein coding gene Chr8:19841402-19841737 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033927
 protein coding gene Chr8:20500016-20505027 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030887
 protein coding gene Chr8:16387351-16387826 (+)
CAST/EiJ MGP_CASTEiJ_G0032450
 protein coding gene Chr8:19289518-19292504 (+)
CBA/J MGP_CBAJ_G0033099
 protein coding gene Chr8:21337987-21338322 (+)
DBA/2J MGP_DBA2J_G0033254
 protein coding gene Chr8:19015755-19016090 (+)
FVB/NJ MGP_FVBNJ_G0033198
 protein coding gene Chr8:18787982-18793169 (+)
LP/J MGP_LPJ_G0033343
 protein coding gene Chr8:19673207-19676317 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033241
 protein coding gene Chr8:20950061-20953657 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033946
 protein coding gene Chr8:19572684-19575794 (+)
PWK/PhJ MGP_PWKPhJ_G0032162
 protein coding gene Chr8:18613134-18616223 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031996
 protein coding gene Chr8:18948401-18952483 (+)
WSB/EiJ MGP_WSBEiJ_G0032567
 protein coding gene Chr8:19721598-19757851 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 246085 NCBI Gene Model | MGI Sequence Detail 3111 C57BL/6J ±  kb
transcript NM_139225 RefSeq | MGI Sequence Detail 298 C57BL/6  
polypeptide Q8R2I8 UniProt | EBI | MGI Sequence Detail 73 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 2
References
more
  • Summaries
    All 15
    Gene Ontology 1
    Phenotypes 3
  • Earliest
    J:75063 Schutte BC, et al., Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2129-33
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory