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Defb7 Gene Detail
Summary
  • Symbol
    Defb7
  • Name
    defensin beta 7
  • Synonyms
    Defb15, mBD7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179200
    NCBI Gene: 246080
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:19545113-19547791 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.35 cM, cytoband A3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179200
 protein coding gene Chr8:19545113-19547791 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033421
 protein coding gene Chr8:17027409-17030059 (+)
A/J MGP_AJ_G0033402
 protein coding gene Chr8:16488929-16490550 (+)
AKR/J MGP_AKRJ_G0033331
 protein coding gene Chr8:16999325-17001969 (+)
BALB/cJ MGP_BALBcJ_G0033402
 protein coding gene Chr8:16579289-16581939 (+)
C3H/HeJ MGP_C3HHeJ_G0033113
 protein coding gene Chr8:17225400-17228050 (+)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0032437
 protein coding gene Chr8:17000108-17002669 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0033242
 protein coding gene Chr8:16389303-16392184 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0033334
 protein coding gene Chr8:17059425-17062102 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033227
 protein coding gene Chr8:18547448-18550098 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033933
 protein coding gene Chr8:16962658-16965258 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0032554
 protein coding gene Chr8:17003335-17006022 (+)



Homology
more
  • Human Ortholog
    DEFB4A, defensin beta 4A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFB4A, defensin beta 4A
  • Synonyms
    BD-2, DEFB102, DEFB2, DEFB-2, DEFB4, HBD-2, SAP1
  • Links
    NCBI Gene ID: 1673
    neXtProt AC: NX_O15263
    UniProt: O15263

  • Chr Location
    8p23.1
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 246080 NCBI Gene Model | MGI Sequence Detail 2679 C57BL/6J ±  kb
transcript NM_139220 RefSeq | MGI Sequence Detail 306 Not Specified  
polypeptide Q91V70 UniProt | EBI | MGI Sequence Detail 71 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 2
References
more
  • Summaries
    All 22
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:75063 Schutte BC, et al., Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2129-33
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory