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Inpp5j Gene Detail
Summary
  • Symbol
    Inpp5j
  • Name
    inositol polyphosphate 5-phosphatase J
  • Synonyms
    Pib5pa, Pipp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158663
    NCBI Gene: 170835
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:3444375-3454821 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 2.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    201 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2158663
 protein coding gene Chr11:3444272-3455521 (-)
129S1/SvImJ ENSMUSG00200031753
 protein coding gene Chr11:397560-408004 (-)
A/J ENSMUSG00195022875
 protein coding gene Chr11:304914-315362 (-)
AKR/J ENSMUSG00220008349
 protein coding gene Chr11:318136-328582 (-)
BALB/cJ ENSMUSG00180024188
 protein coding gene Chr11:327937-338382 (-)
C3H/HeJ ENSMUSG00175009415
 protein coding gene Chr11:317613-328060 (-)
C57BL/6NJ ENSMUSG00215028406
 protein coding gene Chr11:327949-338396 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016012
 protein coding gene Chr11:321141-331612 (-)
CAST/EiJ ENSTCUG00005035968
 protein coding gene Chr11:417702-428148 (-)
CBA/J ENSMUSG00210017646
 protein coding gene Chr11:317253-327698 (-)
DBA/2J ENSMUSG00185016544
 protein coding gene Chr11:414976-425423 (-)
FVB/NJ ENSMUSG00205029954
 protein coding gene Chr11:288302-298748 (-)
JF1/MsJ ENSUMUG00000043662
 protein coding gene Chr11:570474-580910 (-)
LP/J ENSMUSG00230031781
 protein coding gene Chr11:1480753-1491197 (-)
NOD/ShiLtJ ENSMUSG00190029069
 protein coding gene Chr11:304818-315262 (-)
NZO/HlLtJ ENSMUSG00225025354
 protein coding gene Chr11:3537871-3548314 (-)
PWK/PhJ ENSLUMG00010017739
 protein coding gene Chr11:302046-312482 (-)
SPRET/EiJ ENSMSPG00010008408
 protein coding gene Chr11:391311-401730 (-)
WSB/EiJ ENSIUOG00005007124
 protein coding gene Chr11:318727-329171 (-)



Homology
more
  • Human Ortholog
    INPP5J, inositol polyphosphate-5-phosphatase J
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INPP5J, inositol polyphosphate-5-phosphatase J
  • Synonyms
    INPP5, PIB5PA, PIPP
  • Links
    NCBI Gene ID: 27124
    UniProt: Q15735

  • Chr Location
    22q12.2; chr22:31122614-31134697 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are viable, fertile, and show normal mammary gland development and no spontaneous mammary tumors. However, in an oncogene-driven breast cancer mouse model, mice show increased mammary hyperplasia and tumor growth paradoxically associated with reduced lung metastases.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    691
  • Tissues
    94
  • cDNA Data
    21
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034570 Ensembl Gene Model | MGI Sequence Detail 10447 C57BL/6J ±  kb
transcript ENSMUST00000044507 Ensembl | MGI Sequence Detail 3370 Not Applicable  
polypeptide ENSMUSP00000046625 Ensembl | MGI Sequence Detail 1003 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 21

    Microarray probesets 3
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Gene Ontology 11
    Phenotypes 8
  • Earliest
    J:82579 Gurung R, et al., Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation. J Biol Chem. 2003 Mar 28;278(13):11376-85
  • Latest
    J:378493 Ooms LM, et al., Non-redundant roles of the phosphoinositide phosphatases PTEN and PIPP in PI3K/AKT signaling in breast cancer. Commun Biol. 2025 Dec 17;9(1):96
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory