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Cd209d Gene Detail
Summary
  • Symbol
    Cd209d
  • Name
    CD209d antigen
  • Synonyms
    mSIGNR3, SIGN-R3, SIGNR3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2157947
    NCBI Gene: 170779
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:3921824-3928548 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 1.92 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    230 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2157947
 protein coding gene Chr8:3921824-3928555 (-)
129S1/SvImJ ENSMUSG00200009987
 protein coding gene Chr8:748670-755420 (-)
A/J ENSMUSG00195008621
 protein coding gene Chr8:1147085-1153818 (-)
AKR/J ENSMUSG00220010431
 protein coding gene Chr8:873631-880362 (-)
BALB/cJ ENSMUSG00180004576
 protein coding gene Chr8:797573-804304 (-)
C3H/HeJ ENSMUSG00175007837
 protein coding gene Chr8:912167-918898 (-)
C57BL/6NJ ENSMUSG00215005459
 protein coding gene Chr8:826540-833271 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030785
 protein coding gene Chr8:742668-749454 (-)
CAST/EiJ ENSTCUG00005018886
 protein coding gene Chr8:838357-845122 (-)
CBA/J ENSMUSG00210010585
 protein coding gene Chr8:789729-796458 (-)
DBA/2J ENSMUSG00185003590
 protein coding gene Chr8:925786-932517 (-)
FVB/NJ ENSMUSG00205005187
 protein coding gene Chr8:859614-866345 (-)
JF1/MsJ ENSUMUG00000029207
 protein coding gene Chr8:885606-892360 (-)
LP/J ENSMUSG00230005703
 protein coding gene Chr8:3095358-3102089 (-)
NOD/ShiLtJ ENSMUSG00190010548
 protein coding gene Chr8:899799-906530 (-)
NZO/HlLtJ ENSMUSG00225015713
 protein coding gene Chr8:10947060-10953804 (-)
PWK/PhJ ENSLUMG00010010167
 protein coding gene Chr8:824697-831444 (-)
SPRET/EiJ ENSMSPG00010016852
 protein coding gene Chr8:789581-796243 (-)
WSB/EiJ ENSIUOG00005004686
 protein coding gene Chr8:820766-827492 (-)



Homology
more
  • Human Ortholog
    CD209, CD209 molecule
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD209, CD209 molecule
  • Synonyms
    CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1, hDC-SIGN
  • Links
    NCBI Gene ID: 30835
    UniProt: Q9NNX6

  • Chr Location
    19p13.2; chr19:7739993-7747564 (-)  GRCh38
  • Human Ortholog
    CLEC4M, C-type lectin domain family 4 member M
  • Synonyms
    CD209L, CD209L1, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN
  • Links
    NCBI Gene ID: 10332
    UniProt: Q9H2X3

  • Chr Location
    19p13.2; chr19:7763153-7769606 (+)  GRCh38
Human Diseases
more
  • Diseases
    10 with human CD209,CLEC4M associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit normal susceptibility to bacterial infection despite decreased T and B cell proliferation and extramedullary hematopoiesis in the spleen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 170779 NCBI Gene Model | MGI Sequence Detail 6725 C57BL/6J ±  kb
    transcript NM_130904 RefSeq | MGI Sequence Detail 880 C57BL/6  
    polypeptide Q91ZW8 UniProt | EBI | MGI Sequence Detail 237 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 1
      cDNA 7

      Microarray probesets 2
    References
    more
    • Summaries
      All 43
      Gene Ontology 8
      Phenotypes 14
    • Earliest
      J:72165 Park CG, et al., Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN. Int Immunol. 2001 Oct;13(10):1283-90
    • Latest
      J:297421 Malamud M, et al., Immunostimulation by Lactobacillus kefiri S-layer proteins with distinct glycosylation patterns requires different lectin partners. J Biol Chem. 2020 Oct 16;295(42):14430-14444
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory