About   Help   FAQ
Ptpn7 Gene Detail
Summary
  • Symbol
    Ptpn7
  • Name
    protein tyrosine phosphatase, non-receptor type 7
  • Synonyms
    BPTP-4, C920001D21Rik, LC-PTP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2156893
    NCBI Gene: 320139
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:135060438-135073055 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 58.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    143 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2156893
protein coding gene Chr1:135059577-135073064 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016516
protein coding gene Chr1:138868674-138880048 (+)
A/J MGP_AJ_G0016499
protein coding gene Chr1:133625693-133638160 (+)
AKR/J MGP_AKRJ_G0016464
protein coding gene Chr1:137602997-137615489 (+)
BALB/cJ MGP_BALBcJ_G0016459
protein coding gene Chr1:133939405-133952010 (+)
C3H/HeJ MGP_C3HHeJ_G0016285
protein coding gene Chr1:137696509-137712024 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016920
protein coding gene Chr1:143895378-143908818 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014631
protein coding gene Chr1:126736885-126749459 (+)
CAST/EiJ MGP_CASTEiJ_G0015865
protein coding gene Chr1:136770022-136783755 (+)
CBA/J MGP_CBAJ_G0016258
protein coding gene Chr1:148852484-148871103 (+)
DBA/2J MGP_DBA2J_G0016364
protein coding gene Chr1:132626919-132639831 (+)
FVB/NJ MGP_FVBNJ_G0016363
protein coding gene Chr1:131263768-131276552 (+)
LP/J MGP_LPJ_G0016435
protein coding gene Chr1:140112175-140125169 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016388
protein coding gene Chr1:154555606-154569199 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016956
protein coding gene Chr1:137347753-137364491 (+)
PWK/PhJ MGP_PWKPhJ_G0015651
protein coding gene Chr1:131649392-131660839 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015438
protein coding gene Chr1:136311369-136323984 (+)
WSB/EiJ MGP_WSBEiJ_G0015928
protein coding gene Chr1:137377789-137390639 (+)



Homology
more
  • Human Ortholog
    PTPN7, protein tyrosine phosphatase non-receptor type 7
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPN7, protein tyrosine phosphatase non-receptor type 7
  • Synonyms
    BPTP-4, HEPTP, LC-PTP, LPTP, PTPNI
  • Links
    NCBI Gene ID: 5778
    neXtProt AC: NX_P35236
    UniProt: P35236

  • Chr Location
    1q32.1; chr1:202147013-202161588 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    3 involving Ptpn7
  • Incidental Mutations
  • Find Mice (IMSR)
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031506 Ensembl Gene Model | MGI Sequence Detail 12618 C57BL/6J ±  kb
transcript ENSMUST00000187985 Ensembl | MGI Sequence Detail 1990 Not Applicable  
polypeptide ENSMUSP00000141133 Ensembl | MGI Sequence Detail 359 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013462 tyrosine-protein phosphatase non-receptor type 7
  • EC
  • InterPro Domains
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR008356 Protein-tyrosine phosphatase, KIM-containing
    IPR029021 Protein-tyrosine phosphatase-like
    IPR000242 Tyrosine-specific protein phosphatase, PTPase domain
    IPR000387 Tyrosine-specific protein phosphatases domain
Molecular
Reagents
less
  • All nucleic 30
    cDNA 30

    Microarray probesets 1
Other
Accession IDs
less
MGI:2443461
References
more
  • Summaries
    All 29
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:281144 Inamdar VV, et al., The protein tyrosine phosphatase PTPN7 is a negative regulator of ERK activation and thromboxane generation in platelets. J Biol Chem. 2019 Aug 16;294(33):12547-12554

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory