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Lnx2 Gene Detail
Summary
  • Symbol
    Lnx2
  • Name
    ligand of numb-protein X 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155959
    NCBI Gene: 140887
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:146953465-147013385 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 86.69 cM, cytoband G2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    462 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155959
protein coding gene Chr5:146953465-147013396 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030383
protein coding gene Chr5:152641743-152705753 (-)
A/J MGP_AJ_G0030356
protein coding gene Chr5:146179799-146242468 (-)
AKR/J MGP_AKRJ_G0030283
protein coding gene Chr5:150666583-150728176 (-)
BALB/cJ MGP_BALBcJ_G0030365
protein coding gene Chr5:147392597-147453737 (-)
C3H/HeJ MGP_C3HHeJ_G0030079
protein coding gene Chr5:151632901-151696480 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030820
protein coding gene Chr5:158225745-158291441 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028033
protein coding gene Chr5:140594571-140655612 (-)
CAST/EiJ MGP_CASTEiJ_G0029481
protein coding gene Chr5:151187913-151249651 (-)
CBA/J MGP_CBAJ_G0030057
protein coding gene Chr5:164812072-164876395 (-)
DBA/2J MGP_DBA2J_G0030201
protein coding gene Chr5:145862856-145922886 (-)
FVB/NJ MGP_FVBNJ_G0030155
protein coding gene Chr5:145057361-145120253 (-)
LP/J MGP_LPJ_G0030288
protein coding gene Chr5:153334922-153396109 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030191
protein coding gene Chr5:167124709-167185634 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030850
protein coding gene Chr5:150575908-150635777 (-)
PWK/PhJ MGP_PWKPhJ_G0029195
protein coding gene Chr5:144942551-145004010 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029031
protein coding gene Chr5:147897913-147959468 (-)
WSB/EiJ MGP_WSBEiJ_G0029558
protein coding gene Chr5:151360090-151422118 (-)



Homology
more
  • Human Ortholog
    LNX2, ligand of numb-protein X 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LNX2, ligand of numb-protein X 2
  • Synonyms
    PDZRN1
  • Links
    NCBI Gene ID: 222484
    neXtProt AC: NX_Q8N448
    UniProt: Q8N448

  • Chr Location
    13q12.2; chr13:27545913-27621107 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 140887 NCBI Gene Model | MGI Sequence Detail 59921 C57BL/6J ±  kb
transcript NM_001424754 RefSeq | MGI Sequence Detail 4538 C57BL/6  
polypeptide Q91XL2 UniProt | EBI | MGI Sequence Detail 687 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    cDNA 48
    Primer pair 1
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141172
References
more
  • Summaries
    All 40
    Developmental Gene Expression 9
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:73266 Rice D S, et al., The Lnx family proteins function as molecular scaffolds for Numb family proteins. Mol Cell Neurosci. 2001 Nov;18(5):525-40
  • Latest
    J:332924 Lee SJ, et al., Impaired Blastocyst Formation in Lnx2-Knockdown Mouse Embryos. Int J Mol Sci. 2023 Jan 10;24(2)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory