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Gpr6 Gene Detail
Summary
  • Symbol
    Gpr6
  • Name
    G protein-coupled receptor 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2155249
    NCBI Gene: 140741
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:40945973-40948281 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 22.08 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2155249
 protein coding gene Chr10:40945973-40948286 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017169
 protein coding gene Chr10:39708301-39710598 (-)
A/J MGP_AJ_G0017146
 protein coding gene Chr10:38601628-38603924 (-)
AKR/J MGP_AKRJ_G0017106
 protein coding gene Chr10:39166179-39168475 (-)
BALB/cJ MGP_BALBcJ_G0017108
 protein coding gene Chr10:38672790-38675086 (-)
C3H/HeJ MGP_C3HHeJ_G0016929
 protein coding gene Chr10:39482312-39484608 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017567
 protein coding gene Chr10:40918943-40921239 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015263
 protein coding gene Chr10:36552512-36554811 (-)
CAST/EiJ MGP_CASTEiJ_G0016508
 protein coding gene Chr10:39684782-39687079 (-)
CBA/J MGP_CBAJ_G0016903
 protein coding gene Chr10:42781249-42783545 (-)
DBA/2J MGP_DBA2J_G0017008
 protein coding gene Chr10:38105762-38108058 (-)
FVB/NJ MGP_FVBNJ_G0017003
 protein coding gene Chr10:37596061-37598357 (-)
LP/J MGP_LPJ_G0017085
 protein coding gene Chr10:39675289-39677586 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017033
 protein coding gene Chr10:43600122-43602418 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017604
 protein coding gene Chr10:39135040-39137336 (-)
PWK/PhJ MGP_PWKPhJ_G0016288
 protein coding gene Chr10:37996191-37998488 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016072
 protein coding gene Chr10:38968785-38971083 (-)
WSB/EiJ MGP_WSBEiJ_G0016571
 protein coding gene Chr10:39476170-39478466 (-)



Homology
more
  • Human Ortholog
    GPR6, G protein-coupled receptor 6
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR6, G protein-coupled receptor 6
  • Links
    NCBI Gene ID: 2830
    neXtProt AC: NX_P46095
    UniProt: P46095

  • Chr Location
    6q21; chr6:109978256-109980720 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene does not appear to result in a phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    906
  • Tissues
    129
  • cDNA Data
    6
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000046922 Ensembl Gene Model | MGI Sequence Detail 2309 C57BL/6J ±  kb
    transcript ENSMUST00000061796 Ensembl | MGI Sequence Detail 1786 Not Applicable  
    polypeptide ENSMUSP00000057323 Ensembl | MGI Sequence Detail 363 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 6
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143693, MGI:2685079
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 11
      Gene Ontology 3
      Phenotypes 15
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:290119 Soleilhavoup C, et al., Nolz1 expression is required in dopaminergic axon guidance and striatal innervation. Nat Commun. 2020 Jun 19;11(1):3111
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory