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Nop53 Gene Detail
Summary
  • Symbol
    Nop53
  • Name
    NOP53 ribosome biogenesis factor
  • Synonyms
    9430097C02Rik, Gltscr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2154441
    NCBI Gene: 68077
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:15671760-15680033 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 8.64 cM, cytoband A2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2154441
 protein coding gene Chr7:15670108-15680033 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031694
 protein coding gene Chr7:13582332-13590585 (-)
A/J MGP_AJ_G0031666
 protein coding gene Chr7:13397025-13405296 (-)
AKR/J MGP_AKRJ_G0031591
 protein coding gene Chr7:13687092-13695366 (-)
BALB/cJ MGP_BALBcJ_G0031673
 protein coding gene Chr7:13496911-13505175 (-)
C3H/HeJ MGP_C3HHeJ_G0031395
 protein coding gene Chr7:13863832-13872097 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032139
 protein coding gene Chr7:14322271-14332387 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029218
 protein coding gene Chr7:14951987-14961825 (-)
CAST/EiJ MGP_CASTEiJ_G0030746
 protein coding gene Chr7:10633099-10642970 (-)
CBA/J MGP_CBAJ_G0031354
 protein coding gene Chr7:14775903-14784157 (-)
DBA/2J MGP_DBA2J_G0031510
 protein coding gene Chr7:13284821-13293073 (-)
FVB/NJ MGP_FVBNJ_G0031466
 protein coding gene Chr7:13164961-13173205 (-)
LP/J MGP_LPJ_G0031595
 protein coding gene Chr7:13855960-13866169 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031501
 protein coding gene Chr7:14761042-14769281 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032168
 protein coding gene Chr7:13468684-13476897 (-)
PWK/PhJ MGP_PWKPhJ_G0030470
 protein coding gene Chr7:10786789-10796962 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030298
 protein coding gene Chr7:8391828-8401646 (-)
WSB/EiJ MGP_WSBEiJ_G0030843
 protein coding gene Chr7:13503762-13513560 (-)



Homology
more
  • Human Ortholog
    NOP53, NOP53 ribosome biogenesis factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOP53, NOP53 ribosome biogenesis factor
  • Synonyms
    GLTSCR2, PICT1, PICT-1
  • Links
    NCBI Gene ID: 29997
    neXtProt AC: NX_Q9NZM5
    UniProt: Q9NZM5

  • Chr Location
    19q13.33; chr19:47745546-47757058 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout is pre-implantation embryonic lethal. Heterozygous knockout reduces incidence of chemically induced skin papilloma.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    1
  • cDNA Data
    269
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68077 NCBI Gene Model | MGI Sequence Detail 8274 C57BL/6J ±  kb
transcript NM_133831 RefSeq | MGI Sequence Detail 1572 ZRU/MplStud  
polypeptide Q8BK35 UniProt | EBI | MGI Sequence Detail 484 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 272
    Genomic 3
    cDNA 269

    Microarray probesets 4
Other
Accession IDs
less
MGI:1915327, MGI:1924654, MGI:2138595
References
more
  • Summaries
    All 38
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:241062 Sasaki M, et al., Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11. Nat Med. 2011 Jul 31;17(8):944-51
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory