About   Help   FAQ
Dmbx1 Gene Detail
Summary
  • Symbol
    Dmbx1
  • Name
    diencephalon/mesencephalon homeobox 1
  • Synonyms
    Atx, Cdmx, Dmbx1, Mbx, Otx3
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153518
    NCBI Gene: 140477
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:115772316-115797123 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.07 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    623 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153518
 protein coding gene Chr4:115772316-115797794 (-)
129S1/SvImJ ENSMUSG00200044819
 protein coding gene Chr4:109668189-109692893 (-)
A/J ENSMUSG00195046017
 protein coding gene Chr4:110939281-110963763 (-)
AKR/J ENSMUSG00220010400
 protein coding gene Chr4:110280763-110305462 (-)
BALB/cJ ENSMUSG00180040451
 protein coding gene Chr4:109012149-109036624 (-)
C3H/HeJ ENSMUSG00175038074
 protein coding gene Chr4:110026578-110051051 (-)
C57BL/6NJ ENSMUSG00215029581
 protein coding gene Chr4:111095508-111120317 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026320
 protein coding gene Chr4:106351488-106376386 (-)
CAST/EiJ ENSTCUG00005021877
 protein coding gene Chr4:109795694-109820665 (-)
CBA/J ENSMUSG00210052226
 protein coding gene Chr4:109640101-109664578 (-)
DBA/2J ENSMUSG00185047822
 protein coding gene Chr4:111165046-111189523 (-)
FVB/NJ ENSMUSG00205028552
 protein coding gene Chr4:109109614-109134089 (-)
JF1/MsJ ENSUMUG00000034631
 protein coding gene Chr4:111059986-111085004 (-)
LP/J ENSMUSG00230044761
 protein coding gene Chr4:114485511-114510204 (-)
NOD/ShiLtJ ENSMUSG00190028450
 protein coding gene Chr4:109008468-109032944 (-)
NZO/HlLtJ ENSMUSG00225010627
 protein coding gene Chr4:119972901-119997590 (-)
PWK/PhJ ENSLUMG00010044231
 protein coding gene Chr4:108466035-108491042 (-)
SPRET/EiJ ENSMSPG00010027196
 protein coding gene Chr4:110533689-110558695 (-)
WSB/EiJ ENSIUOG00005043553
 protein coding gene Chr4:109323194-109348010 (-)



Homology
more
  • Human Ortholog
    DMBX1, diencephalon/mesencephalon homeobox 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DMBX1, diencephalon/mesencephalon homeobox 1
  • Synonyms
    Atx, MBX, OTX3, PAXB
  • Links
    NCBI Gene ID: 127343
    UniProt: Q8NFW5

  • Chr Location
    1p33; chr1:46489822-46516218 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 6 alleles in 4 genetic backgrounds
    4 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele display partial postnatal lethality, impaired suckling and postnatal growth, and reduced female fertility. When raised in isolation, mice homozygous for another null allele exhibit decreased body weight, decreased food consumption, and small adipocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1118
  • Tissues
    320
  • cDNA Data
    16
  • Literature Summary
    34
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028707 Ensembl Gene Model | MGI Sequence Detail 24808 C57BL/6J ±  kb
    transcript ENSMUST00000084338 Ensembl | MGI Sequence Detail 4031 Not Applicable  
    polypeptide ENSMUSP00000081366 Ensembl | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 16
      Primer pair 7
      Other 10

      Microarray probesets 3
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 34
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:72725 Martinez-Barbera JP, et al., Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2. Development. 2001 Dec;128(23):4789-800
    • Latest
      J:363327 Sepp M, et al., Cellular development and evolution of the mammalian cerebellum. Nature. 2024 Jan;625(7996):788-796
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory