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Rims1 Gene Detail
Summary
  • Symbol
    Rims1
  • Name
    regulating synaptic membrane exocytosis 1
  • Synonyms
    C030033M19Rik, RIM1, RIM1a, RIM1alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152971
    NCBI Gene: 116837
  • Alliance
    genome feature page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:22356475-22845203 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 8.54 cM, cytoband A5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15678 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152971
 protein coding gene Chr1:22356196-22845239 (-)
129S1/SvImJ ENSMUSG00200018594
 protein coding gene Chr1:19763832-19773890 (-)
129S1/SvImJ ENSMUSGG00200054746
 protein coding gene Chr1:19928955-19958330 (-)
A/J ENSMUSG00195027297
 protein coding gene Chr1:19530546-19540816 (-)
A/J ENSMUSGG00195055288
 protein coding gene Chr1:19701840-19731222 (-)
AKR/J ENSMUSGG00220054782
 protein coding gene Chr1:19747347-19776729 (-)
AKR/J ENSMUSG00220007944
 protein coding gene Chr1:19576073-19586341 (-)
BALB/cJ ENSMUSG00180023545
 protein coding gene Chr1:19616370-19626451 (-)
BALB/cJ ENSMUSGG00180055403
 protein coding gene Chr1:19787557-19816944 (-)
C3H/HeJ ENSMUSG00175000119
 protein coding gene Chr1:19521726-19531996 (-)
C3H/HeJ ENSMUSGG00175054557
 protein coding gene Chr1:19693010-19722395 (-)
C57BL/6NJ ENSMUSG00215011286
 protein coding gene Chr1:19615635-19625716 (-)
C57BL/6NJ ENSMUSGG00215055582
 protein coding gene Chr1:19780737-19810112 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013992
 protein coding gene Chr1:17851823-18340739 (-)
CAST/EiJ no annotation
CBA/J ENSMUSGG00210054757
 protein coding gene Chr1:19569309-19598694 (-)
CBA/J ENSMUSG00210002717
 protein coding gene Chr1:19398023-19408295 (-)
DBA/2J ENSMUSGG00185057777
 protein coding gene Chr1:20613629-20643013 (-)
DBA/2J ENSMUSG00185016420
 protein coding gene Chr1:20442332-20452602 (-)
FVB/NJ ENSMUSG00205013755
 protein coding gene Chr1:19525415-19535685 (-)
FVB/NJ ENSMUSGG00205054355
 protein coding gene Chr1:19696720-19726103 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055683
 protein coding gene Chr1:20625160-20654542 (-)
LP/J ENSMUSG00230000154
 protein coding gene Chr1:20453881-20464151 (-)
NOD/ShiLtJ ENSMUSGG00190054842
 protein coding gene Chr1:19699939-19729323 (-)
NOD/ShiLtJ ENSMUSG00190027861
 protein coding gene Chr1:19528795-19538876 (-)
NZO/HlLtJ ENSMUSG00225000314
 protein coding gene Chr1:23747361-23757442 (-)
NZO/HlLtJ ENSMUSGG00225055262
 protein coding gene Chr1:23912430-23941792 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010026402
 protein coding gene Chr1:20243065-20737215 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    RIMS1, regulating synaptic membrane exocytosis 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RIMS1, regulating synaptic membrane exocytosis 1
  • Synonyms
    CORD7, RAB3IP2, RIM, RIM1
  • Links
    NCBI Gene ID: 22999
    UniProt: Q86UR5

  • Chr Location
    6q13; chr6:71886550-72403150 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 4 alleles in 5 genetic backgrounds
    14 phenotypes from multigenic genotypes
    66 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display defects in maternal care and abnormalities in synaptic transmission in the central nervous system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    78
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    627
  • Tissues
    23
  • cDNA Data
    8
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      170
    • RefSeq
      100
    • UniProt
      10
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041670 Ensembl Gene Model | MGI Sequence Detail 488729 C57BL/6J ±  kb
    transcript ENSMUST00000097809 Ensembl | MGI Sequence Detail 7172 Not Applicable  
    polypeptide ENSMUSP00000095418 Ensembl | MGI Sequence Detail 1666 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 9
      Primer pair 2
      Antibodies 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1924723
    References
    more
    • Summaries
      All 122
      Developmental Gene Expression 8
      Gene Ontology 23
      Phenotypes 66
    • Earliest
      J:57915 Wang X, et al., Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin. J Cell Biol. 1999 Oct 4;147(1):151-62
    • Latest
      J:389879 Emperador-Melero J, et al., Deployment of endocytic machinery to periactive zones of nerve terminals is independent of active zone assembly and evoked release. Elife. 2026 Jun 17;14
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory