About   Help   FAQ
Helb Gene Detail
Summary
  • Symbol
    Helb
  • Name
    helicase (DNA) B
  • Synonyms
    D10Ertd664e
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152895
    NCBI Gene: 117599
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:119919513-119948892 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 67.94 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1097 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152895
 protein coding gene Chr10:119919513-119948917 (-)
129S1/SvImJ ENSMUSG00200025506
 protein coding gene Chr10:116270320-116299703 (-)
A/J ENSMUSG00195021429
 protein coding gene Chr10:116673078-116702481 (-)
AKR/J ENSMUSG00220014233
 protein coding gene Chr10:116305766-116335151 (-)
BALB/cJ ENSMUSG00180015939
 protein coding gene Chr10:116685646-116715053 (-)
C3H/HeJ ENSMUSG00175024247
 protein coding gene Chr10:116690465-116719844 (-)
C57BL/6NJ ENSMUSG00215011710
 protein coding gene Chr10:116329257-116358643 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015846
 protein coding gene Chr10:112713038-112742657 (-)
CAST/EiJ ENSTCUG00005030742
 protein coding gene Chr10:115653788-115683422 (-)
CBA/J ENSMUSG00210021249
 protein coding gene Chr10:116527252-116556635 (-)
DBA/2J ENSMUSG00185007703
 protein coding gene Chr10:116637048-116666451 (-)
FVB/NJ ENSMUSG00205022132
 protein coding gene Chr10:115934952-115964359 (-)
JF1/MsJ ENSUMUG00000017820
 protein coding gene Chr10:117912697-117942307 (-)
LP/J ENSMUSG00230024485
 protein coding gene Chr10:118598282-118627696 (-)
NOD/ShiLtJ ENSMUSG00190017005
 protein coding gene Chr10:116737790-116767201 (-)
NZO/HlLtJ ENSMUSG00225036438
 protein coding gene Chr10:122848276-122877679 (-)
PWK/PhJ ENSLUMG00010012816
 protein coding gene Chr10:116316895-116346535 (-)
SPRET/EiJ ENSMSPG00010015617
 protein coding gene Chr10:118238239-118267451 (-)
WSB/EiJ ENSIUOG00005013089
 protein coding gene Chr10:116373559-116402959 (-)



Homology
more
  • Human Ortholog
    HELB, DNA helicase B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HELB, DNA helicase B
  • Synonyms
    DHB, hDHB
  • Links
    NCBI Gene ID: 92797
    UniProt: Q8NG08

  • Chr Location
    12q14.3; chr12:66302493-66343643 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout MEFs display increased DNA end resection, resulting in increased level of single-strand DNA formation at double-strand DNA breaks.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    36
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020228 Ensembl Gene Model | MGI Sequence Detail 29380 C57BL/6J ±  kb
transcript ENSMUST00000020449 Ensembl | MGI Sequence Detail 4554 Not Applicable  
polypeptide ENSMUSP00000020449 Ensembl | MGI Sequence Detail 1074 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 36
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1289215, MGI:2143601
References
more
  • Summaries
    All 47
    Gene Ontology 11
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory