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Dner Gene Detail
Summary
  • Symbol
    Dner
  • Name
    delta/notch-like EGF repeat containing
  • Synonyms
    A930026D19Rik, BET, MGC:39059
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152889
    NCBI Gene: 227325
  • Alliance
    genome feature page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:84347560-84673942 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 43.40 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    7898 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152889
 protein coding gene Chr1:84347560-84673942 (-)
129S1/SvImJ ENSMUSG00200036757
 protein coding gene Chr1:82025603-82352167 (-)
A/J ENSMUSG00195027302
 protein coding gene Chr1:81440137-81769328 (-)
AKR/J ENSMUSG00220038471
 protein coding gene Chr1:81801697-82114140 (-)
BALB/cJ ENSMUSG00180014302
 protein coding gene Chr1:81696741-82023373 (-)
C3H/HeJ ENSMUSG00175001014
 protein coding gene Chr1:81856850-82186196 (-)
C57BL/6NJ ENSMUSG00215020551
 protein coding gene Chr1:81774192-82100815 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014338
 protein coding gene Chr1:77451046-77753094 (-)
CAST/EiJ ENSTCUG00005006950
 protein coding gene Chr1:81422190-81727548 (-)
CBA/J ENSMUSG00210012183
 protein coding gene Chr1:81604494-81916902 (-)
DBA/2J ENSMUSG00185015451
 protein coding gene Chr1:82653458-82980047 (-)
FVB/NJ ENSMUSG00205021298
 protein coding gene Chr1:81169786-81500462 (-)
JF1/MsJ ENSUMUG00000007446
 protein coding gene Chr1:81466179-81795682 (-)
LP/J ENSMUSG00230013062
 protein coding gene Chr1:82590049-82917643 (-)
NOD/ShiLtJ ENSMUSG00190024912
 protein coding gene Chr1:81822649-82135097 (-)
NZO/HlLtJ ENSMUSG00225003535
 protein coding gene Chr1:85834928-86161443 (-)
PWK/PhJ ENSLUMG00010043564
 protein coding gene Chr1:81076081-81387486 (-)
SPRET/EiJ ENSMSPG00010043619
 protein coding gene Chr1:83396390-83724726 (-)
WSB/EiJ ENSIUOG00005035507
 protein coding gene Chr1:81336543-81645162 (-)



Homology
more
  • Human Ortholog
    DNER, delta/notch like EGF repeat containing
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNER, delta/notch like EGF repeat containing
  • Synonyms
    bet, UNQ26
  • Links
    NCBI Gene ID: 92737
    UniProt: Q8NFT8

  • Chr Location
    2q36.3; chr2:229357629-229714581 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display delayed cerebellar development, abnormal Bergmann glial cells, abnormal Purkinje cell innervation, and impaired coordination.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1265
  • Tissues
    111
  • cDNA Data
    54
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 227325 NCBI Gene Model | MGI Sequence Detail 326383 C57BL/6J ±  kb
    transcript NM_152915 RefSeq | MGI Sequence Detail 3664 Not Specified  
    polypeptide Q8JZM4 UniProt | EBI | MGI Sequence Detail 737 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000006599 delta and Notch-like epidermal growth factor-related receptor
      (term hierarchy)
    • InterPro Domains
      IPR045769 Delta and Notch-like epidermal growth factor-related receptor, C-terminal
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR000152 EGF-type aspartate/asparagine hydroxylation site
      IPR009030 Growth factor receptor cysteine-rich domain superfamily
    • GlyGen
      Q8JZM4 5 sites, 8 N-linked glycans (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 54
      Primer pair 1
      Antibodies 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2444360
    References
    more
    • Summaries
      All 70
      Developmental Gene Expression 21
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:377446 Kumari R, et al., Retrograde control of sympathetic neuron-satellite glia interactions by target-derived NGF signaling. Cell Rep. 2025 Dec 23;44(12):116697
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory