Trim66 MGI Mouse Gene Detail - MGI:2152406 - tripartite motif-containing 66

Symbol

Trim66
Name

tripartite motif-containing 66
Synonyms

D7H11orf29, Tif1d

Feature Type

protein coding gene
IDs

MGI:2152406
NCBI Gene: 330627
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr7:109048213-109107341 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 57.21 cM
Mapping Data

1 experiment

SNPs within 2kb

1810 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2152406	protein coding gene	Chr7:109048208-109115948 (-)
129S1/SvImJ	ENSMUSG00200031369	protein coding gene	Chr7:95589805-95648926 (-)
A/J	ENSMUSG00195054004	protein coding gene	Chr7:100085967-100145127 (-)
AKR/J	ENSMUSG00220038046	protein coding gene	Chr7:93489415-93548583 (-)
BALB/cJ	ENSMUSG00180039144	protein coding gene	Chr7:96761190-96820324 (-)
C3H/HeJ	ENSMUSG00175047776	protein coding gene	Chr7:97397180-97456312 (-)
C57BL/6NJ	ENSMUSG00215049967	protein coding gene	Chr7:96701997-96761135 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030308	protein coding gene	Chr7:111660781-111721068 (-)
CAST/EiJ	ENSTCUG00005051398	protein coding gene	Chr7:100071889-100132233 (-)
CBA/J	ENSMUSG00210034596	protein coding gene	Chr7:97224325-97283457 (-)
DBA/2J	ENSMUSG00185020134	protein coding gene	Chr7:101574584-101633722 (-)
FVB/NJ	ENSMUSG00205043044	protein coding gene	Chr7:97186563-97245690 (-)
JF1/MsJ	ENSUMUG00000037901	protein coding gene	Chr7:106588873-106648637 (-)
LP/J	ENSMUSG00230042367	protein coding gene	Chr7:107675619-107734751 (-)
NOD/ShiLtJ	ENSMUSG00190039223	protein coding gene	Chr7:97384636-97444110 (-)
NZO/HlLtJ	ENSMUSG00225015552	protein coding gene	Chr7:105893990-105953143 (-)
PWK/PhJ	ENSLUMG00010037506	protein coding gene	Chr7:95705798-95766074 (-)
SPRET/EiJ	ENSMSPG00010037375	protein coding gene	Chr7:96868087-96922989 (-)
WSB/EiJ	ENSIUOG00005045560	protein coding gene	Chr7:98019505-98079587 (-)

Human Ortholog

TRIM66, tripartite motif containing 66

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TRIM66, tripartite motif containing 66
Synonyms

C11orf29, TIF1D, TIF1DELTA
Links

HGNC:29005

NCBI Gene ID: 9866

UniProt: O15016
Chr Location

11p15.4; chr11:8612037-8683231 (-) GRCh38

MGI Vertebrate Homology

Trim66 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TRIM66
Gene Tree

Trim66

less

Phenotype Summary

8 phenotypes from 3 alleles in 3 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

6
Radiation induced

1
Targeted

4
Transgenic

1
Genomic Mutations

3 involving Trim66
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

57 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null males, but not females, sire pups that are overweight at birth, indicating a paternal effect on intrauterine overgrowth.

less

All GO Annotations

19
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

607
Tissues

1
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase trim66

ZFIN trim66

less

All Sequences

62
RefSeq

20
UniProt

5
CCDS

CCDS40082.1, CCDS52359.1, CCDS52360.1

Ensembl

ENSMUSG00000031026 (Evidence)
NCBI Gene

330627

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031026	Ensembl Gene Model \| MGI Sequence Detail	59129	C57BL/6J	± kb
transcript	ENSMUST00000106741	Ensembl \| MGI Sequence Detail	4417	Not Applicable
polypeptide	ENSMUSP00000102352	Ensembl \| MGI Sequence Detail	1344	Not Applicable

less

UniProt

5 Sequences
Protein Ontology

PR:000016664 tripartite motif-containing protein 66

(term hierarchy)
PDB

7EBJ, 7EBK
InterPro Domains

IPR003649 B-box, C-terminal

IPR000315 B-box-type zinc finger

IPR001487 Bromodomain

IPR036427 Bromodomain-like superfamily

IPR037372 Tripartite motif-containing protein 66, B-box type 1 zinc finger

IPR011011 Zinc finger, FYVE/PHD-type

IPR019787 Zinc finger, PHD-finger

IPR001965 Zinc finger, PHD-type

IPR019786 Zinc finger, PHD-type, conserved site

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type

IPR017907 Zinc finger, RING-type, conserved site
GlyGen

Q924W6 1 site

less

All nucleic 12

Genomic 1

cDNA 11

Microarray probesets 2

Summaries

All 49

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 21
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:376267 Bao H, et al., An epigenetic repressor TRIM66 dictates monogenic olfactory receptor expression, neural activity, and olfactory behavior. Nat Commun. 2025 Dec 12;16(1):11091

TSS for Trim66:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr74183	Chr7:109093244-109093274 (-)	14,082 bp
Tssr74182	Chr7:109092834-109092848 (-)	14,500 bp
Tssr74181	Chr7:109055834-109055865 (-)	51,491 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24