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Taf4b Gene Detail
Summary
  • Symbol
    Taf4b
  • Name
    TATA-box binding protein associated factor 4b
  • Synonyms
    105kDa, 2610524B04Rik, 4932409F03Rik, Taf2c2, TAFII105
  • Feature Type
    protein coding gene
  • IDs
    MGI:2152345
    NCBI Gene: 72504
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:14916302-15033416 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 8.28 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    454 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2152345
 protein coding gene Chr18:14916302-15035160 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024170
 protein coding gene Chr18:12071875-12196131 (+)
A/J MGP_AJ_G0024132
 protein coding gene Chr18:11822973-11943793 (+)
AKR/J MGP_AKRJ_G0024099
 protein coding gene Chr18:12217094-12346463 (+)
BALB/cJ MGP_BALBcJ_G0024131
 protein coding gene Chr18:11763691-11884980 (+)
C3H/HeJ MGP_C3HHeJ_G0023898
 protein coding gene Chr18:12057323-12180039 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024576
 protein coding gene Chr18:12663774-12784930 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022016
 protein coding gene Chr18:11325451-11445141 (+)
CAST/EiJ MGP_CASTEiJ_G0023375
 protein coding gene Chr18:11959245-12086248 (+)
CBA/J MGP_CBAJ_G0023870
 protein coding gene Chr18:12824165-12958886 (+)
DBA/2J MGP_DBA2J_G0023999
 protein coding gene Chr18:11643526-11762190 (+)
FVB/NJ MGP_FVBNJ_G0023964
 protein coding gene Chr18:11485435-11601089 (+)
LP/J MGP_LPJ_G0024082
 protein coding gene Chr18:12186687-12308205 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023993
 protein coding gene Chr18:12950959-13086295 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024622
 protein coding gene Chr18:11956152-12076459 (+)
PWK/PhJ MGP_PWKPhJ_G0023121
 protein coding gene Chr18:11748017-11866651 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022930
 protein coding gene Chr18:12221152-12339965 (+)
WSB/EiJ MGP_WSBEiJ_G0023441
 protein coding gene Chr18:11924568-12045295 (+)



Homology
more
  • Human Ortholog
    TAF4B, TATA-box binding protein associated factor 4b
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAF4B, TATA-box binding protein associated factor 4b
  • Synonyms
    SPGF13, TAF2C2, TAFII105
  • Links
    NCBI Gene ID: 6875
    neXtProt AC: NX_Q92750
    UniProt: Q92750

  • Chr Location
    18q11.2; chr18:26226445-26391685 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TAF4B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 1 allele in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null male mice are initially fertile but show progressive germ cell loss, seminiferous tubule degeneration and spermatogonia defects leading to sterility. Females are sterile and show premature ovarian aging, persistent estrous, elevated FSH levels and reduced primordial follicle numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    836
  • Tissues
    118
  • cDNA Data
    44
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054321 Ensembl Gene Model | MGI Sequence Detail 117115 C57BL/6J ±  kb
    transcript ENSMUST00000169862 Ensembl | MGI Sequence Detail 5149 Not Applicable  
    polypeptide ENSMUSP00000126909 Ensembl | MGI Sequence Detail 855 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      cDNA 44
      Primer pair 3

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1919754, MGI:2147380
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 14
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:342170 Gura MA, et al., Transcription and chromatin regulation by TAF4b during cellular quiescence of developing prospermatogonia. Front Cell Dev Biol. 2023;11:1270408
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory