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Cts3 Gene Detail
Summary
  • Symbol
    Cts3
  • Name
    cathepsin 3
  • Synonyms
    1600000I23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151929
    NCBI Gene: 117066
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:61712444-61717941 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 32.74 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    204 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151929
 protein coding gene Chr13:61712444-61717984 (-)
129S1/SvImJ ENSMUSG00200014705
 protein coding gene Chr13:58580901-58662255 (-)
A/J ENSMUSG00195043114
 protein coding gene Chr13:58144678-58150169 (-)
AKR/J ENSMUSG00220038231
 protein coding gene Chr13:57640547-57646044 (-)
BALB/cJ ENSMUSG00180014655
 protein coding gene Chr13:58353947-58359438 (-)
C3H/HeJ ENSMUSG00175033704
 protein coding gene Chr13:58114777-58120274 (-)
C57BL/6NJ ENSMUSG00215035575
 protein coding gene Chr13:58122492-58127989 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018629
 protein coding gene Chr13:56873820-56879390 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210031127
 protein coding gene Chr13:58319629-58325126 (-)
DBA/2J ENSMUSG00185014974
 protein coding gene Chr13:59168243-59173740 (-)
FVB/NJ ENSMUSG00205041951
 protein coding gene Chr13:57893201-57898710 (-)
JF1/MsJ ENSUMUG00000011207
 protein coding gene Chr13:58549880-58555371 (-)
LP/J ENSMUSG00230028573
 protein coding gene Chr13:68532989-68538494 (-)
NOD/ShiLtJ ENSMUSG00190025903
 protein coding gene Chr13:58243219-58248741 (-)
NZO/HlLtJ ENSMUSG00225046014
 protein coding gene Chr13:62218685-62224182 (-)
PWK/PhJ ENSLUMG00010021186
 protein coding gene Chr13:57474475-57480012 (-)
SPRET/EiJ ENSMSPG00010038761
 protein coding gene Chr13:57850263-57855798 (-)
WSB/EiJ ENSIUOG00005024934
 protein coding gene Chr13:57691382-57696873 (-)



Homology
more
  • Human Ortholog
    CTSL, cathepsin L
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTSL, cathepsin L
  • Synonyms
    CATL, CTSL1, MEP
  • Links
    NCBI Gene ID: 1514
    UniProt: P07711

  • Chr Location
    9q21.33; chr9:87724051-87731469 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CTSL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    26
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    641
  • Tissues
    30
  • cDNA Data
    44
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074870 Ensembl Gene Model | MGI Sequence Detail 5498 C57BL/6J ±  kb
transcript ENSMUST00000223815 Ensembl | MGI Sequence Detail 1367 Not Applicable  
polypeptide ENSMUSP00000153399 Ensembl | MGI Sequence Detail 332 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR013201 Cathepsin propeptide inhibitor domain (I29)
    IPR025660 Cysteine peptidase, histidine active site
    IPR039417 Papain-like cysteine endopeptidase
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR013128 Peptidase C1A
    IPR000668 Peptidase C1A, papain C-terminal
  • GlyGen
    Q91ZD5 1 site
Molecular
Reagents
less
  • All nucleic 47
    cDNA 45
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1916256
References
more
  • Summaries
    All 34
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory