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Calcb Gene Detail
Summary
  • Symbol
    Calcb
  • Name
    calcitonin-related polypeptide, beta
  • Synonyms
    Calc2, CGRP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2151254
    NCBI Gene: 116903
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:114317878-114322600 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 60.19 cM, cytoband F3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2151254
 protein coding gene Chr7:114315790-114322603 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032885
 protein coding gene Chr7:118397894-118402647 (+)
A/J MGP_AJ_G0032868
 protein coding gene Chr7:115425542-115430825 (+)
AKR/J MGP_AKRJ_G0032800
 protein coding gene Chr7:118343386-118348200 (+)
BALB/cJ MGP_BALBcJ_G0032873
 protein coding gene Chr7:115127073-115131790 (+)
C3H/HeJ MGP_C3HHeJ_G0032583
 protein coding gene Chr7:118307526-118312246 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033379
 protein coding gene Chr7:123147795-123152526 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030351
 protein coding gene Chr7:116947070-116951753 (+)
CAST/EiJ MGP_CASTEiJ_G0031911
 protein coding gene Chr7:109956279-109962281 (+)
CBA/J MGP_CBAJ_G0032556
 protein coding gene Chr7:127263530-127270169 (+)
DBA/2J MGP_DBA2J_G0032708
 protein coding gene Chr7:113472921-113477637 (+)
FVB/NJ MGP_FVBNJ_G0032661
 protein coding gene Chr7:113339718-113344484 (+)
LP/J MGP_LPJ_G0032802
 protein coding gene Chr7:119899553-119904297 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032693
 protein coding gene Chr7:128861783-128866496 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033399
 protein coding gene Chr7:117319471-117324203 (+)
PWK/PhJ MGP_PWKPhJ_G0031619
 protein coding gene Chr7:106351404-106356108 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031466
 protein coding gene Chr7:104060268-104064969 (+)
WSB/EiJ MGP_WSBEiJ_G0032024
 protein coding gene Chr7:118192971-118197680 (+)



Homology
more
  • Human Ortholog
    CALCB, calcitonin related polypeptide beta
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CALCB, calcitonin related polypeptide beta
  • Synonyms
    CALC2, CGRP2, CGRP-II
  • Links
    NCBI Gene ID: 797
    neXtProt AC: NX_P10092
    UniProt: P10092

  • Chr Location
    11p15.2; chr11:14904997-15082342 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CALCA associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    894
  • Tissues
    160
  • cDNA Data
    8
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030666 Ensembl Gene Model | MGI Sequence Detail 4723 C57BL/6J ±  kb
    transcript ENSMUST00000182816 Ensembl | MGI Sequence Detail 706 Not Applicable  
    polypeptide ENSMUSP00000138713 Ensembl | MGI Sequence Detail 156 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 8
      Primer pair 1
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 6
      Gene Ontology 2
      Phenotypes 17
    • Earliest
      J:61682 Hagiwara N, et al., Sox6 is a candidate gene for p100H myopathy, heart block, and sudden neonatal death. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4180-5
    • Latest
      J:330605 Yang D, et al., Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection. Cell. 2022 Oct 27;185(22):4190-4205.e25
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory