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S1pr5 Gene Detail
Summary
  • Symbol
    S1pr5
  • Name
    sphingosine-1-phosphate receptor 5
  • Synonyms
    Edg8, lpB4, S1P5
  • Feature Type
    protein coding gene
  • IDs
    MGI:2150641
    NCBI Gene: 94226
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21154213-21159739 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.75 cM, cytoband A4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2150641
protein coding gene Chr9:21154208-21159739 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034445
protein coding gene Chr9:18436393-18442973 (-)
A/J MGP_AJ_G0034423
protein coding gene Chr9:18128725-18134296 (-)
AKR/J MGP_AKRJ_G0034350
protein coding gene Chr9:18456010-18463008 (-)
BALB/cJ MGP_BALBcJ_G0034414
protein coding gene Chr9:18020770-18026143 (-)
C3H/HeJ MGP_C3HHeJ_G0034126
protein coding gene Chr9:18765329-18770773 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034935
protein coding gene Chr9:19177709-19183208 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031865
protein coding gene Chr9:17255618-17261632 (-)
CAST/EiJ MGP_CASTEiJ_G0033449
protein coding gene Chr9:18593664-18598599 (-)
CBA/J MGP_CBAJ_G0034099
protein coding gene Chr9:19903401-19908878 (-)
DBA/2J MGP_DBA2J_G0034258
protein coding gene Chr9:18103085-18108277 (-)
FVB/NJ MGP_FVBNJ_G0034201
protein coding gene Chr9:17631428-17636940 (-)
LP/J MGP_LPJ_G0034343
protein coding gene Chr9:18611851-18618796 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034244
protein coding gene Chr9:21508755-21516239 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034955
protein coding gene Chr9:18416165-18421145 (-)
PWK/PhJ MGP_PWKPhJ_G0033155
protein coding gene Chr9:18084295-18090101 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032989
protein coding gene Chr9:18466265-18473335 (-)
WSB/EiJ MGP_WSBEiJ_G0033564
protein coding gene Chr9:18140318-18145518 (-)



Homology
more
  • Human Ortholog
    S1PR5, sphingosine-1-phosphate receptor 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    S1PR5, sphingosine-1-phosphate receptor 5
  • Synonyms
    Edg-8, EDG8, S1P5, SPPR-1, SPPR-2
  • Links
    NCBI Gene ID: 53637
    neXtProt AC: NX_Q9H228
    UniProt: Q9H228

  • Chr Location
    19p13.2; chr19:10512742-10517965 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Bone marrow from mice homozygous for a knock-out allele induces impaired NK cell egression from the lymph nodes and bone marrow.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 94226 NCBI Gene Model | MGI Sequence Detail 5527 C57BL/6J ±  kb
transcript NM_053190 RefSeq | MGI Sequence Detail 2512 C57BL/6  
polypeptide Q91X56 UniProt | EBI | MGI Sequence Detail 400 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 9
    Primer pair 3
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 59
    Developmental Gene Expression 13
    Gene Ontology 5
    Phenotypes 21
  • Earliest
    J:71372 Ishii I, et al., Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3. J Biol Chem. 2001 Sep 7;276(36):33697-704
  • Latest
    J:335038 Behrangi N, et al., Siponimod ameliorates metabolic oligodendrocyte injury via the sphingosine-1 phosphate receptor 5. Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2204509119

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory