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Clic1 Gene Detail
Summary
  • Symbol
    Clic1
  • Name
    chloride intracellular channel 1
  • Synonyms
    Clcp, G6
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148924
    NCBI Gene: 114584
  • Alliance
    genome feature page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35269219-35277695 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.58 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148924
 protein coding gene Chr17:35268942-35277725 (+)
129S1/SvImJ ENSMUSG00200050585
 protein coding gene Chr17:30973049-30981846 (+)
A/J ENSMUSG00195039489
 protein coding gene Chr17:31873074-31881811 (+)
AKR/J ENSMUSG00220050911
 protein coding gene Chr17:30901969-30910691 (+)
BALB/cJ ENSMUSG00180035021
 protein coding gene Chr17:31242939-31251672 (+)
C3H/HeJ ENSMUSG00175032413
 protein coding gene Chr17:30788081-30796808 (+)
C57BL/6NJ ENSMUSG00215051972
 protein coding gene Chr17:30813262-30822057 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021495
 protein coding gene Chr17:31790594-31799680 (+)
CAST/EiJ ENSTCUG00005049434
 protein coding gene Chr17:31830776-31839498 (+)
CBA/J ENSMUSG00210049116
 protein coding gene Chr17:30610177-30618900 (+)
DBA/2J ENSMUSG00185044986
 protein coding gene Chr17:33262191-33270924 (+)
FVB/NJ ENSMUSG00205036088
 protein coding gene Chr17:31130582-31139324 (+)
JF1/MsJ ENSUMUG00000056944
 protein coding gene Chr17:32514563-32523358 (+)
LP/J ENSMUSG00230054626
 protein coding gene Chr17:34371300-34380099 (+)
NOD/ShiLtJ ENSMUSG00190052585
 protein coding gene Chr17:30731854-30740648 (+)
NZO/HlLtJ ENSMUSG00225054280
 protein coding gene Chr17:36383567-36392325 (+)
PWK/PhJ ENSLUMG00010038320
 protein coding gene Chr17:30349769-30358541 (+)
SPRET/EiJ ENSMSPG00010034215
 protein coding gene Chr17:31533831-31542460 (+)
WSB/EiJ ENSIUOG00005045220
 protein coding gene Chr17:31459096-31467836 (+)



Homology
more
  • Human Ortholog
    CLIC1, CLIC family member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLIC1, CLIC family member 1
  • Synonyms
    CL1C1, CLCNL1, G6, NCC27
  • Links
    NCBI Gene ID: 1192
    UniProt: O00299

  • Chr Location
    6p21.33; chr6:31730581-31740558 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormal platelet number, activation and aggregation and prolonged bleeding time.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    44
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    620
  • Tissues
    12
  • cDNA Data
    268
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 114584 NCBI Gene Model | MGI Sequence Detail 8477 C57BL/6J ±  kb
transcript NM_033444 RefSeq | MGI Sequence Detail 1159 C57BL/6  
polypeptide Q9Z1Q5 UniProt | EBI | MGI Sequence Detail 241 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000005574 chloride intracellular channel protein 1
    (term hierarchy)
  • EC
    1.8.-.-, 1.8.5.1
  • InterPro Domains
    IPR030259 Chloride intracellular channel protein 1, C-terminal domain
    IPR053823 CLIC, N-terminal domain
    IPR036282 Glutathione S-transferase, C-terminal domain superfamily
    IPR010987 Glutathione S-transferase, C-terminal-like
    IPR040079 Glutathione transferase family
    IPR002946 Intracellular chloride channel
    IPR036249 Thioredoxin-like superfamily
  • GlyGen
    Q9Z1Q5 3 sites, 1 N-linked glycan (2 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 272
    Genomic 1
    cDNA 268
    Primer pair 3
    Antibodies 1

    Microarray probesets 2
References
more
  • Summaries
    All 59
    Developmental Gene Expression 6
    Gene Ontology 11
    Phenotypes 17
  • Earliest
    J:55639 Ribas G, et al., Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region. J Immunol. 1999 Jul 1;163(1):278-87
  • Latest
    J:358253 Ko M, et al., Inhibition of chloride intracellular channel protein 1 (CLIC1) ameliorates liver fibrosis phenotype by activating the Ca(2+)-dependent Nrf2 pathway. Biomed Pharmacother. 2023 Dec;168:115776
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory